Molecular structure of Guanabenz acetate, CAS Number: 23256-50-0
Guanabenz acetate (CAS 23256-50-0)
See product citations (2)
Application:
Guanabenz acetate is an α2A-AR agonist and IGRS selective ligand
CAS Number:
23256-50-0
Purity:
≥98%
Molecular Weight:
291.14
Molecular Formula:
C8H8Cl2N4•CH3CO2H
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Guanabenz acetate (GBA) is a derivative of guanabenz, an alkaloid found in the bark of the guanabana tree. It is an alpha2A-AR adrenergic agonist and IGRS (imidazoline I2 binding site) selective ligand. It is also an activator of alpha2B-AR (alpha2b-adrenergic receptor) and alpha2C-AR (alpha2c-adrenergic receptor). Guanabenz acetate inhibits the release of norepinephrine, a neurotransmitter involved in the regulation of blood pressure. It may act to have antioxidant, anti-inflammatory, and antinociceptive activity in vitro.
Guanabenz acetate (CAS 23256-50-0) References
- Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions. | Tribouillard-Tanvier, D., et al. 2008. PLoS One. 3: e1981. PMID: 18431471
- In silico fasciolicide activity of three experimental compounds in sheep. | Ibarra-Velarde, F., et al. 2008. Ann N Y Acad Sci. 1149: 183-5. PMID: 19120206
- Involvement of postsynaptic alpha 2-adrenoceptors and guanine nucleotide-binding protein in guanabenz-induced cardiovascular suppressant effects in the rat. | Chen, CH. and Chan, SH. 1989. Neurosci Lett. 105: 183-8. PMID: 2562061
- Effects of guanabenz acetate on the pacemaker activity of rabbit sinoatrial node cells. | Kotake, H., et al. 1989. Arch Int Pharmacodyn Ther. 300: 209-17. PMID: 2619423
- Guanabenz Treatment Accelerates Disease in a Mutant SOD1 Mouse Model of ALS. | Vieira, FG., et al. 2015. PLoS One. 10: e0135570. PMID: 26288094
- Autophagy participates in the unfolded protein response in Toxoplasma gondii. | Nguyen, HM., et al. 2017. FEMS Microbiol Lett. 364: PMID: 28859319
- The roles of alpha 2-adrenoceptors in the nucleus reticularis gigantocellularis and vagal mechanism in the cardiovascular suppressive effects of guanabenz in the rat. | Lim, HC. and Chan, SH. 1986. Neurosci Lett. 63: 45-50. PMID: 3005924
- Guanabenz Acetate Induces Endoplasmic Reticulum Stress-Related Cell Death in Hepatocellular Carcinoma Cells. | Kang, HJ., et al. 2019. J Pathol Transl Med. 53: 94-103. PMID: 30646673
- [Guanabenz acetate and serum lipids. Sequential evaluation during one year]. | Spritzer, N., et al. 1988. Arq Bras Cardiol. 51: 193-7. PMID: 3075114
- Sinoatrial and atrioventricular dysfunction associated with the use of guanabenz acetate. | LaRusso, P., et al. 1988. Can J Cardiol. 4: 146-8. PMID: 3378199
- Participation of nucleus reticularis gigantocellularis in guanabenz-promoted hypotension, decrease in cardiac contractility and bradycardia in rats. | Lim, HC., et al. 1985. Neuropharmacology. 24: 1241-6. PMID: 4094659
- Inhibition of hepatic cholesterol and triglyceride synthesis by guanabenz acetate. | Capuzzi, DM. and Cevallos, WH. 1984. J Cardiovasc Pharmacol. 6 Suppl 5: S847-52. PMID: 6084138
Inhibitor of:
(eukaryotic translation initiation factor) eIF1, (eukaryotic translation initiation factor) eIF5, 9030025P20Rik, ADAR3, ATF-6, CCDC47, CPN reg, CREB3L2, eIF2β, eIF2C3, FAM134A_Fam134a, GADD 153, GCH-I, GLT8D2, HRI, KDEL ER Marker, KDEL receptor 2, MGC29506, N-CoR, Olfr773, PKR, PPP1R15B, RECS1, scotin, SDF-2L1, SDF-4, Sec63, SPCS2, TIA-1, TMTC4, Torsin3A, Torsin4A, and WRB.Activator of:
alpha2A-AR, alpha2B-AR, alpha2C-AR, ATF-6α, BAP29, CCDC132, DnaJC10, eIF2Bα, eIF2S3, ERp27, ERp46, golgin 45, HERPUD2, HRI, HSPA14, MCFD2, REEP6, Sec31A, Sec61α1, Sec62, Shigatoxin 1, TCP-1 α, TEX264, and TMX3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Guanabenz acetate, 100 mg | sc-203590 | 100 mg | $102.00 | |||
Guanabenz acetate, 500 mg | sc-203590A | 500 mg | $468.00 | |||
Guanabenz acetate, 1 g | sc-203590B | 1 g | $832.00 | |||
Guanabenz acetate, 10 g | sc-203590C | 10 g | $4162.00 | |||
Guanabenz acetate, 25 g | sc-203590D | 25 g | $7283.00 |