GOLGA6C Inhibitors
GOLGA6C inhibitors denote a class of chemical compounds that target the GOLGA6C protein, a constituent of the golgin subfamily of proteins which are predominantly localized to the Golgi apparatus and potentially play roles in maintaining Golgi structure and function. These inhibitors are designed to impede the activity of GOLGA6C through various mechanisms, often by interrupting the biochemical pathways that enable its function. The precise mechanisms of action can vary, with some inhibitors binding directly to the GOLGA6C protein, thereby altering its conformation and disabling its ability to interact with other molecular partners. Others may work indirectly by modulating the signaling pathways that regulate the protein's activity or localization. For instance, certain inhibitors may prevent post-translational modifications of GOLGA6C that are necessary for its activity, while others could impede the trafficking of vesicles that carry GOLGA6C to the Golgi apparatus. The intricacies of GOLGA6C's role mean that the inhibitors have to be highly specific to avoid off-target effects that could disrupt other Golgi-associated functions.
The development and classification of GOLGA6C inhibitors are based on an in-depth understanding of the protein's molecular interactions and the pathways it influences. These compounds are a testament to the advances in molecular biology and chemistry that allow for the precise targeting of specific protein functions. Though diverse in structure, GOLGA6C inhibitors are unified by their common goal: to effectively suppress the activity of GOLGA6C. This is achieved without affecting the transcriptional and translational processes that lead to the protein's synthesis. By focusing on the functional aspect, researchers can gain insights into the fundamental workings of GOLGA6C, including how it contributes to the maintenance and dynamics of the Golgi apparatus. These inhibitors are pivotal tools for dissecting the protein's role further, enabling scientists to delineate the contribution of GOLGA6C to cellular processes and its interaction with cellular machinery. As research progresses, the repertoire of GOLGA6C inhibitors continues to expand, offering a growing toolkit for the exploration of Golgi function and protein trafficking within the cellular context.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin specifically binds to FKBP12 and the complex inhibits mTOR (mammalian target of rapamycin). As mTOR is involved in the regulation of protein synthesis and Golgi organization, the inhibition of mTOR can decrease the functional activity of GOLGA6C by disrupting protein trafficking and organelle organization. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A inhibits ADP-ribosylation factor (Arf), a small GTPase involved in Golgi vesicle trafficking. Inhibition of Arf leads to Golgi apparatus disassembly, which would directly affect GOLGA6C by disrupting its localization and function within the Golgi. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is a sodium ionophore that disrupts Golgi function by altering the pH and ion balance within the Golgi compartments. This ion imbalance can lead to a decrease in the functional activity of GOLGA6C by impairing its proper folding and processing. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin blocks N-linked glycosylation by inhibiting the enzyme dolichyl-phosphate N-acetylglucosaminephosphotransferase. As glycosylation is critical for proper protein folding and function in the Golgi, the inhibition of this process can indirectly decrease the activity of GOLGA6C by affecting its post-translational modification. | ||||||
Castanospermine | 79831-76-8 | sc-201358 sc-201358A | 100 mg 500 mg | $180.00 $620.00 | 10 | |
Castanospermine is an inhibitor of glucosidase I and II, enzymes involved in the trimming of glucose residues from N-linked glycoproteins. This inhibition can lead to improper protein folding within the Golgi and potentially reduce the functional activity of GOLGA6C due to the accumulation of misfolded proteins. | ||||||
Swainsonine | 72741-87-8 | sc-201362 sc-201362C sc-201362A sc-201362D sc-201362B | 1 mg 2 mg 5 mg 10 mg 25 mg | $135.00 $246.00 $619.00 $799.00 $1796.00 | 6 | |
Swainsonine inhibits mannosidase II, an enzyme involved in the processing of oligosaccharides on glycoproteins within the Golgi. The inhibition of this enzyme can lead to the mislocalization and dysfunction of GOLGA6C as it affects the maturation of proteins that GOLGA6C may interact with. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization. Given that the Golgi apparatus is closely associated with the microtubule organizing center, the disruption of microtubules can lead to Golgi fragmentation and thus negatively impact GOLGA6C's role within the Golgi. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $187.00 $670.00 | 11 | |
Golgicide A is a specific inhibitor of the Golgi BFA resistance factor 1 (GBF1), which is essential for Golgi and Arf1 function. Inhibition of GBF1 by Golgicide A causes Golgi apparatus disassembly, reducing GOLGA6C activity by disturbing its Golgi localization. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine raises the pH in intracellular organelles, including the Golgi. This pH change can affect the enzymatic activities within the Golgi, thereby disrupting the processing and function of GOLGA6C. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, preventing its polymerization and thus leading to the disruption of microtubules. As microtubules are essential for Golgi structure and function, this disruption can impair GOLGA6C's role in the Golgi. | ||||||