GOLGA6C Activators
GOLGA6C Activators encompass a collection of chemical compounds that enhance the functional activity of GOLGA6C by various means, primarily through the modulation of pathways and processes related to the Golgi apparatus and vesicular trafficking. Forskolin, for instance, indirectly augments the activity of GOLGA6C by increasing intracellular cAMP levels, thereby activating PKA which may phosphorylate proteins that interact with GOLGA6C, enhancing its role in Golgi maintenance and trafficking. In a similar vein, Brefeldin A disrupts Golgi structure by inhibiting ARF, and the subsequent reassembly process may transiently boost GOLGA6C activity. The use of GTPγS and the related Guanosine 5'-O-(3-Thiotriphosphate) ensures the activation of GTPase proteins, which are crucial for the vesicle docking and fusion processes that GOLGA6C is potentially involved in. Monensin and Aluminium fluoride (AlF4-) provoke alterations in the Golgi function and ion homeostasis, promoting compensatory mechanisms that may enhance GOLGA6C's role in the organelle's structural integrity and function.
The cellular dynamics of vesicle trafficking and Golgi maintenance are further influenced by compounds that modulate the availability of pivotal molecules and the state of protein phosphorylation. N-Ethylmaleimide blocks NSF, leading to an accumulation of vesicles, possibly necessitating enhanced GOLGA6C function to manage the surplus trafficking demand. Nicotinamide adenine dinucleotide (NAD+) and ATP provide essential substrates for ADP-ribosylation reactions and the energy for molecular motors, respectively, underpinning the trafficking and maintenance roles of GOLGA6C. Okadaic acid's inhibition of protein phosphatases like PP1 and PP2A results in increased protein phosphorylation, which may indirectly influence GOLGA6C activity by altering the phosphorylation landscape of the Golgi apparatus. Lastly, Piceatannol's inhibition of Syk kinase may enhance GOLGA6C mediated processes by upregulating pathways that rely on vesicle-mediated trafficking, where GOLGA6C is a key player. Collectively, these activators operate through a diverse array of biochemical mechanisms to enhance the functional activity of GOLGA6C within its pivotal role in the Golgi apparatus.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels in cells. Elevated cAMP activates PKA (protein kinase A), which can phosphorylate numerous substrates including those involved in the Golgi apparatus function, potentially enhancing the activity of GOLGA6C by promoting its involvement in Golgi maintenance and trafficking. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts the structure and function of the Golgi apparatus by inhibiting ARF (ADP-ribosylation factor), a small GTPase. As the Golgi apparatus reassembles, the process may transiently increase the activity of GOLGA6C as it participates in the reorganization and maintenance of Golgi structure. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $68.00 $210.00 $780.00 $1880.00 | 19 | |
N-Ethylmaleimide irreversibly inhibits NSF (N-ethylmaleimide-sensitive factor), an ATPase involved in vesicle fusion. Inhibition of NSF can result in an accumulation of vesicles, which could indirectly increase GOLGA6C activity as it may be required to handle the increased vesicular load associated with disrupted trafficking. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ is an essential coenzyme in redox reactions. It also serves as a substrate for ADP-ribosylation reactions that can modify proteins involved in vesicle trafficking. Enhancing ADP-ribosylation may indirectly increase the activity of GOLGA6C through modulation of GOLGI-associated trafficking and maintenance processes. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore that disrupts Golgi function by altering cation transport and pH. The perturbation of the Golgi apparatus may indirectly enhance GOLGA6C's activity by stimulating compensatory mechanisms that GOLGA6C is potentially part of, to maintain Golgi structure and function. | ||||||
Aluminum Fluoride | 7784-18-1 | sc-291881 sc-291881A | 10 g 50 g | $66.00 $245.00 | ||
Aluminium fluoride acts as a phosphate analog and can activate GTPase proteins by mimicking the gamma phosphate of GTP. This can lead to the activation of GTP-binding proteins indirectly involved with GOLGA6C, potentially enhancing its role in Golgi apparatus function and vesicular trafficking. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels of cellular proteins. This can indirectly enhance GOLGA6C activity by modulating the phosphorylation state of proteins involved in maintaining Golgi structure and function. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $50.00 $70.00 $195.00 | 11 | |
Piceatannol inhibits Syk kinase, which can affect vesicle-mediated trafficking and signaling pathways. | ||||||