GNGT2 Inhibitors
GNGT2 inhibitors, while not directly acting on GNGT2, primarily target the intricate G protein signaling pathway, aiming to modulate the signal transduction processes associated with GNGT2. They act on different components of this pathway, from the G proteins themselves to the receptors and channels they interact with. For instance, agents like Pertussis Toxin modify the Gi protein, preventing G protein-coupled receptors (GPCRs) from interacting with it. This alteration in the interaction dynamics affects the broader G protein signaling framework in which GNGT2 plays a role.
Similarly, compounds like YM-254890, UBO-QIC, and BIM-46187 exert their effects on various G proteins, impacting their specific signaling events and, in turn, the larger network of G protein pathways. Another strategic point of action is the GPCRs themselves. SCH-202676, for instance, modulates GPCR's ligand-binding pocket, influencing their interaction with G proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
It modifies the Gi protein, preventing G protein-coupled receptors (GPCRs) from interacting with it, thereby indirectly affecting GNGT2 function. | ||||||
YM 254890 | 568580-02-9 | sc-507356 | 1 mg | $510.00 | ||
Selective inhibitor of Gq protein. While not directly inhibiting GNGT2, it affects related G protein pathways. | ||||||
CGP 57380 | 522629-08-9 | sc-202993 | 5 mg | $172.00 | 6 | |
Inhibits the function of Gi/o proteins. Indirectly affects the broader G protein signaling in which GNGT2 is involved. | ||||||
NF 023 | 104869-31-0 | sc-204124 sc-204124A | 10 mg 50 mg | $161.00 $629.00 | 1 | |
P2 receptor antagonist that can impact G-protein signaling, indirectly influencing pathways associated with GNGT2. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
Cdc42 GTPase inhibitor. While not directly targeting GNGT2, it affects the dynamics of G proteins and their signaling. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Inhibits Protein Kinase C (PKC), which is upstream in many G protein-coupled pathways, potentially affecting the function of GNGT2 indirectly. | ||||||
Thiazovivin | 1226056-71-8 | sc-361380 sc-361380A | 10 mg 25 mg | $284.00 $634.00 | 15 | |
Specific activator of GIRK channels, indirectly affecting G-protein signaling pathways in which GNGT2 operates. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
It acts as a non-selective P2 antagonist, affecting G protein-coupled purinergic signaling, indirectly influencing pathways associated with GNGT2. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $28.00 $39.00 $100.00 $277.00 | 28 | |
Known to inhibit certain ion channels and transporters which can affect GPCR signaling, thereby indirectly impacting the functional landscape in which GNGT2 operates. | ||||||