Gm75 Activators
Akt1 activators are a group of diverse chemical compounds that enhance the activity of Akt1 through various signaling mechanisms. Insulin and IGF-1 are potent activators of the PI3K/Akt pathway; upon binding to their respective receptors, they initiate a cascade that culminates in the phosphorylation and activation of Akt1 by PDK1 and mTORC2. Similarly, SC79 binds directly to Akt1, augmenting its kinase activity by enhancing phosphorylation interactions. The inhibition of Hsp90 by 17-AAG can paradoxically lead to the activation of its client protein Akt1, while phosphatidic acid and arachidonic acid activate mTOR and PDK1, respectively, both of which phosphorylate and activate Akt1. Vanadate, by inhibiting tyrosine phosphatases, may also augment the phosphorylation state and subsequent activity of Akt1.
Additionally, compounds like protocatechuic acid and betulinic acid have been reported to enhance Akt1 phosphorylation, although the pathways through which they do so are not yet fully elucidated. Anisomycin stimulates MAPKs, which may indirectly promote Akt1 activation by activating upstream kinases such as PDK1. Dihydrotestosterone (DHT) interacts with the androgen receptor to potentially trigger Akt1 activation via the PI3K/Akt pathway. Resveratrol, known for activating sirtuins, may indirectly influence Akt1 activity by modulating the PI3K/Akt signaling pathway. Collectively, these Akt1 activators operate through a network of signaling events that converge on the phosphorylation and activation of Akt1, underpinning its critical role in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels which can then activate PKA. PKA phosphorylation could enhance GM75 activity if GM75 is part of a pathway regulated by PKA. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, which degrade cAMP. By preventing cAMP degradation, IBMX can indirectly lead to the activation of PKA and enhancement of GM75 activity if it is cAMP-dependent. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid inhibits protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels. If GM75 function is regulated by phosphorylation, its activity could be indirectly enhanced. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which may enhance GM75 activity if GM75 is downstream of PKC or if PKC directly phosphorylates GM75. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate is a general inhibitor of protein tyrosine phosphatases. This can lead to enhanced tyrosine phosphorylation, potentially increasing GM75 activity if it is regulated by such modifications. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, potentially enhancing GM75 activity if GM75 is calcium-dependent. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. This could enhance GM75 activity if GM75 is regulated by cAMP/PKA signaling. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that also activates stress-activated protein kinases like JNK. GM75 might be activated as part of a stress response. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium levels, which could enhance GM75 activity if it is calcium-dependent. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which can alter signaling pathways and potentially enhance GM75 activity if GM75 is involved in PI3K/Akt signaling. | ||||||