Gm1568 Inhibitors

The class of chemicals described as CCDC177 Inhibitors encompasses a range of compounds with varied effects on the cytoskeleton and cell division machinery. These compounds may not directly target CCDC177 but can interfere with the general cellular functions and structures where coiled-coil domain-containing proteins, such as CCDC177, often play a role.

Compounds like cytochalasin D, latrunculin A, swinholide A, and jasplakinolide act on the actin cytoskeleton, which is a critical component of cell shape, motility, and division. Altering actin dynamics can have downstream effects on proteins that interface with the cytoskeleton, including those with coiled-coil domains. In contrast, nocodazole, paclitaxel, colchicine, vinblastine, vincristine, and griseofulvin target microtubules, which are integral to cell division and intracellular transport. By stabilizing or destabilizing microtubules, these compounds can indirectly influence coiled-coil proteins that are involved in these processes. Withaferin A targets intermediate filaments like vimentin, affecting the structural integrity and signaling functions where coiled-coil proteins may participate. Lastly, Y-27632 inhibits ROCK kinase, a regulator of actin cytoskeleton dynamics, which could potentially impact the cellular roles of coiled-coil domain-containing proteins.