Gm14137 Inhibitors
Gm14137, a predicted gene in Mus musculus, is anticipated to play a crucial role in cellular processes associated with Rho protein signal transduction, positive regulation of cellular component biogenesis, and the regulation of cell shape. Predicted to be located in the mitochondrion and active in the cytoplasm, cytoskeleton, and plasma membrane, Gm14137 shares orthology with the human C15orf62, highlighting its evolutionary conservation and potential functional relevance in biological processes. The predicted involvement in Rho protein signal transduction suggests Gm14137's role in modulating cellular responses governed by Rho GTPases, which are key regulators of cytoskeletal dynamics and cell shape.
Inhibition of Gm14137 encompasses a diverse set of chemical interventions targeting pathways associated with its predicted functions. ROCK inhibitors such as Y-27632 and dual inhibitors of Rho/MRTF/SRF signaling like CCG-1423 directly impact Rho protein signal transduction, potentially disrupting Gm14137's role in this pathway. Actin polymerization inhibitors, including Latrunculin A and Cytochalasin D, influence cytoskeleton dynamics, implicating Gm14137 in the regulation of cell shape. While direct inhibitors specific to Gm14137 may not be identified, indirect approaches involve targeting related pathways such as TGF-β signaling using SB431542 or disrupting the MEK/ERK pathway with PD98059. These inhibitors provide valuable insights into potential regulatory networks governing Gm14137, offering avenues for further exploration of its functional roles in cellular responses related to Rho protein signal transduction, cellular component biogenesis, and cell shape regulation. Understanding the impact of these inhibitors on Gm14137 provides a foundation for unraveling the intricacies of its involvement in cellular processes and potential implications for broader biological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
ROCK inhibitor impacting Rho protein signal transduction. Y-27632 inhibits ROCK, disrupting Rho signaling and potentially influencing Gm14137's role in cellular processes related to Rho protein signal transduction. | ||||||
CCG-1423 | 285986-88-1 | sc-205241 sc-205241A | 1 mg 5 mg | $30.00 $90.00 | 8 | |
Dual inhibitor of Rho/MRTF/SRF signaling. CCG-1423 targets Rho signaling, potentially impacting Gm14137's involvement in Rho protein signal transduction, cellular component biogenesis, and regulation of cell shape. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Actin polymerization inhibitor affecting cytoskeleton dynamics. Latrunculin A disrupts actin dynamics, potentially influencing Gm14137's function in regulating cell shape through its predicted activity in the cytoplasm and cytoskeleton. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
Wnt signaling inhibitor. While not directly targeting Gm14137, IWR-1-endo influences pathways related to cellular component biogenesis, potentially impacting Gm14137's involvement in this process through indirect effects on Wnt signaling pathways. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Actin polymerization inhibitor affecting cytoskeleton dynamics. Cytochalasin D disrupts actin dynamics, potentially influencing Gm14137's function in regulating cell shape through its predicted activity in the cytoplasm and cytoskeleton. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
TGF-β receptor inhibitor indirectly influencing Gm14137. Given Gm14137's potential involvement in TGF-β signaling and cellular component biogenesis, SB431542 disrupts downstream events, potentially impacting Gm14137's expression and functional outcomes. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Myosin II inhibitor affecting cytoskeleton dynamics. Blebbistatin inhibits myosin II, potentially influencing Gm14137's function in regulating cell shape through its activity in the cytoplasm and cytoskeleton, modulating the dynamics of cellular components. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Inhibitor of MEK/ERK pathway, indirectly impacting Gm14137. PD98059 disrupts the MEK/ERK pathway, potentially influencing Gm14137's involvement in cellular processes related to Rho protein signal transduction and regulation of cell shape. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
Arp2/3 complex inhibitor affecting cytoskeleton dynamics. CK-666 inhibits the Arp2/3 complex, potentially influencing Gm14137's involvement in cellular processes related to Rho protein signal transduction and regulation of cell shape. | ||||||