GLT8D3 Inhibitors
The chemical class of GLT8D3 inhibitors comprises compounds targeting epigenetic regulators involved in histone methylation and acetylation. BIX-01294 and UNC0638 are inhibitors of histone methyltransferases G9a and GLP, influencing GLT8D3 by altering chromatin structure and gene expression through epigenetic regulation. EPZ-5676 and GSK343 target enzymes involved in histone methylation (DOT1L and EZH2, respectively), affecting the epigenetic landscape around GLT8D3. CPI-455 and UNC1999 are inhibitors of EZH1/2 and G9a/GLP, respectively, modulating histone methylation patterns and potentially impacting GLT8D3 through epigenetic mechanisms.
DZNep and SGC0946 disrupt histone methylation patterns and arginine methylation, respectively, influencing the epigenetic regulation of genes associated with GLT8D3. C646 and PFI-2 are inhibitors affecting histone acetylation patterns through p300/CBP and BET bromodomain inhibition, respectively, potentially altering GLT8D3 expression or activity through epigenetic mechanisms. A-366 and UNC0642 are G9a inhibitors with improved selectivity, modulating histone methylation patterns and impacting the epigenetic control of genes related to GLT8D3. This diverse set of inhibitors provides a valuable toolkit for investigating the intricate regulatory mechanisms associated with GLT8D3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
Histone methyltransferase inhibitor targeting G9a and GLP. BIX-01294 inhibits the methylation of histone H3 at lysine 9, influencing epigenetic regulation. This may indirectly modulate GLT8D3 by altering chromatin structure and gene expression involved in its regulation. | ||||||
UNC0638 | 1255580-76-7 | sc-397012 | 10 mg | $315.00 | ||
G9a/GLP inhibitor with selectivity over other histone methyltransferases. UNC0638 modulates histone methylation patterns, potentially affecting the epigenetic landscape around GLT8D3. This indirect influence may alter the protein's expression or activity through epigenetic mechanisms. | ||||||
GSK343 | 1346704-33-3 | sc-397025 sc-397025A | 5 mg 25 mg | $151.00 $461.00 | 1 | |
EZH2 inhibitor targeting the PRC2 complex. GSK343 modulates histone methylation by inhibiting EZH2, potentially influencing the epigenetic control of genes associated with GLT8D3. This indirect modulation may affect the protein's expression or activity through alterations in chromatin structure. | ||||||
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
G9a/GLP inhibitor with improved selectivity. UNC1999 influences histone methylation patterns, potentially altering the epigenetic regulation of genes related to GLT8D3. This indirect modulation through epigenetic pathways may contribute to changes in GLT8D3 expression or activity. | ||||||
3-Deazaneplanocin, HCl salt | 120964-45-6 | sc-351856 sc-351856A sc-351856B | 1 mg 5 mg 10 mg | $256.00 $612.00 $936.00 | 2 | |
S-adenosylhomocysteine hydrolase inhibitor affecting histone methylation. DZNep disrupts the methylation status of histones, potentially influencing the epigenetic regulation of genes associated with GLT8D3. This indirect modulation may contribute to alterations in GLT8D3 expression or function. | ||||||
UNC 0642 | 1481677-78-4 | sc-397059 | 10 mg | $235.00 | 3 | |
G9a inhibitor with improved selectivity. UNC0642 modulates histone methylation patterns, potentially impacting the epigenetic control of genes related to GLT8D3. This indirect modulation through epigenetic mechanisms may contribute to changes in GLT8D3 expression or activity. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
p300/CBP inhibitor disrupting histone acetylation. C646 modulates histone acetylation patterns, potentially impacting the epigenetic control of genes related to GLT8D3. This indirect modulation through epigenetic mechanisms may contribute to changes in GLT8D3 expression or activity. | ||||||
A-366 | 1527503-11-2 | sc-507495 | 10 mg | $195.00 | ||
G9a inhibitor with improved selectivity. A-366 modulates histone methylation patterns, potentially impacting the epigenetic control of genes related to GLT8D3. This indirect modulation through epigenetic mechanisms may contribute to changes in GLT8D3 expression or activity. | ||||||