GLI-1 Activators
The chemical class known as GLI-1 activators comprises compounds that modulate the activity of GLI-1, a key transcription factor in the Hedgehog signaling pathway. These activators can directly impact GLI-1 or indirectly influence its transcriptional activity by targeting various signaling pathways and cellular processes. SAG (Smoothened Agonist) directly activates GLI-1 by binding to Smoothened, bypassing upstream negative regulators and promoting GLI-1 transcriptional activity within the Hedgehog pathway. In contrast, GANT61, TAK-441, and LDE225 indirectly activate GLI-1 by inhibiting negative regulatory mechanisms, preventing its processing and activation.
Arsenic Trioxide, Curcumin, Forskolin, 20α-Hydroxy Cholesterol, Vitamin D3, and All-trans Retinoic Acid indirectly activate GLI-1 by influencing the Hedgehog signaling pathway components. They impact the expression or function of negative regulators, promoting GLI-1 transcriptional activity and modulating cellular processes such as tissue development and regeneration. Verteporfin and Arsenic Trisulfide indirectly activate GLI-1 by targeting cross-talk with other signaling pathways. Verteporfin inhibits YAP/TAZ, preventing their negative regulation of GLI-1, while Arsenic Trisulfide influences negative regulators within the Hedgehog pathway.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $63.00 $128.00 $200.00 | 6 | |
GANT61 is a small molecule inhibitor of GLI-1 processing and transcriptional activity. By blocking the function of GLI-1, GANT61 indirectly activates GLI-1 by preventing its negative regulatory mechanisms. This indirect activation contributes to the modulation of the Hedgehog signaling pathway and the regulation of downstream target genes involved in cell differentiation and proliferation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin indirectly activates GLI-1 by modulating cAMP levels. Elevated cAMP levels activate protein kinase A (PKA), which, in turn, inhibits GSK-3β, leading to the stabilization and activation of GLI-1. This indirect activation influences the Hedgehog signaling pathway, impacting cell proliferation and differentiation processes regulated by GLI-1. | ||||||
Verteporfin | 129497-78-5 | sc-475698 sc-475698A | 10 mg 100 mg | $347.00 $2710.00 | 5 | |
Verteporfin is a small molecule inhibitor of YAP/TAZ, indirectly activating GLI-1 by preventing YAP/TAZ-mediated GLI-1 inhibition. This indirect activation influences the cross-talk between Hedgehog and Hippo signaling pathways, modulating cellular processes such as proliferation and stem cell maintenance. | ||||||
SAG | 912545-86-9 | sc-212905 sc-212905A | 1 mg 5 mg | $163.00 $413.00 | 27 | |
SAG is a Smoothened agonist that directly activates the Hedgehog signaling pathway, leading to the activation of GLI-1. By binding to Smoothened, SAG bypasses upstream negative regulators and promotes GLI-1 transcriptional activity. This direct activation influences Hedgehog signaling-mediated cellular processes, including embryonic development and tissue homeostasis. | ||||||
20α-Hydroxy Cholesterol | 516-72-3 | sc-209393 | 10 mg | $300.00 | ||
20α-Hydroxy Cholesterol indirectly activates GLI-1 by inhibiting Hedgehog signaling pathway negative regulators. This compound influences the modulation of GLI-1 transcriptional activity, contributing to Hedgehog pathway-mediated cellular processes such as tissue development and regeneration. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 indirectly activates GLI-1 by modulating Hedgehog pathway components. It impacts the expression of Hedgehog signaling regulators, promoting GLI-1 transcriptional activity. This indirect activation influences Hedgehog pathway-mediated cellular processes, including tissue development and maintenance. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
All-trans Retinoic Acid (ATO) indirectly activates GLI-1 by influencing Hedgehog pathway components. ATO has been shown to modulate the expression of Hedgehog signaling regulators, leading to increased GLI-1 transcriptional activity. This indirect activation impacts cellular processes such as embryonic development and tissue homeostasis. | ||||||
Erismodegib | 956697-53-3 | sc-396280 sc-396280A | 10 mg 100 mg | $255.00 $918.00 | ||
LDE225 is a small molecule inhibitor of Smoothened, indirectly activating GLI-1 by preventing Smoothened-mediated inhibition. This indirect activation contributes to the modulation of the Hedgehog signaling pathway, influencing cellular processes such as cell proliferation and differentiation regulated by GLI-1. | ||||||