Date published: 2025-12-24

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GK5 Inhibitors

GK5 inhibitors belong to a specialized category of chemical compounds designed to target and modulate the activity of GK5, which stands for Golgi Kinase 5. GK5 is a protein kinase enzyme that is part of the Golgi apparatus, an essential cellular organelle involved in protein modification, sorting, and transport. The precise functions of GK5 are still being elucidated, but it is believed to play roles in regulating Golgi structure, vesicle trafficking, and potentially cellular signaling pathways. Inhibitors of GK5 are developed to interact with this specific kinase, potentially influencing its catalytic activity, substrate specificity, or its participation in cellular processes related to Golgi function and intracellular transport. Structurally, GK5 inhibitors are meticulously designed to engage specific regions or binding sites on the GK5 kinase. This interaction may disrupt the normal functioning of GK5, potentially affecting its ability to phosphorylate target proteins or its involvement in intracellular transport and signaling cascades. The mechanisms by which GK5 inhibitors exert their effects can vary, but their primary objective is to serve as valuable tools for researchers studying the roles of GK5 in various cellular contexts. Investigating the biochemical and functional aspects of GK5 and its modulation by inhibitors can contribute to a deeper understanding of Golgi function, protein trafficking, and the broader field of molecular and cellular biology. Ultimately, such research can offer insights into the intricate molecular mechanisms that govern fundamental cellular functions and their potential regulation by GK5.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Azaserine

115-02-6sc-29063
sc-29063A
50 mg
250 mg
$306.00
$906.00
15
(3)

An inhibitor of glutamine amidotransferase enzymes. It may affect metabolic pathways and possibly disrupt GK5's role in glycerolipid metabolism.

2-Deoxy-D-glucose

154-17-6sc-202010
sc-202010A
1 g
5 g
$65.00
$210.00
26
(2)

A glucose analog that acts as a competitive inhibitor for glucose metabolizing enzymes. It can potentially interfere with enzymes in related pathways, such as GK5.

5-Thio-D-glucose

20408-97-3sc-221044A
sc-221044B
sc-221044
25 mg
100 mg
1 g
$143.00
$377.00
$1275.00
3
(0)

Another glucose analog that can inhibit various enzymes in glucose metabolism. It may have an indirect effect on GK5 activity or expression.

2,3-Dimethoxy-5-methyl-p-benzoquinone

605-94-7sc-213956
sc-213956A
1 g
5 g
$57.00
$157.00
(1)

A fatty acid analog known to inhibit lipid metabolism. It could potentially affect GK5's role in glycerolipid metabolism.

R-(+)-Etomoxir

124083-20-1sc-208201A
sc-208201
2 mg
5 mg
$245.00
$430.00
(0)

An inhibitor of carnitine palmitoyltransferase, impacting fatty acid metabolism. This can indirectly influence GK5's metabolic pathway.

AICAR

2627-69-2sc-200659
sc-200659A
sc-200659B
50 mg
250 mg
1 g
$60.00
$270.00
$350.00
48
(2)

An AMP-activated protein kinase activator, it affects several metabolic pathways and might indirectly influence GK5 activity or expression.

Oxamic acid

471-47-6sc-250620
25 g
$145.00
(0)

An inhibitor of lactate dehydrogenase, it affects glycolysis and might have downstream effects influencing GK5.

Ritonavir

155213-67-5sc-208310
10 mg
$122.00
7
(1)

Known primarily as an antiretroviral, it has effects on lipid metabolism. This could potentially influence GK5's role in glycerolipid metabolism.

Atorvastatin

134523-00-5sc-337542A
sc-337542
50 mg
100 mg
$252.00
$495.00
9
(1)

A statin drug that inhibits cholesterol synthesis. Given the interplay of lipid metabolism pathways, it might indirectly affect GK5.

Fenofibrate

49562-28-9sc-204751
5 g
$40.00
9
(1)

Affects lipid metabolism by activating PPARα. This can potentially have downstream effects on enzymes like GK5 involved in glycerolipid metabolism.