GGH Activators
GGH, short for Gamma-Glutamyl Hydrolase, is an enzyme that plays a crucial role in the metabolism of glutathione, a key antioxidant molecule in the human body. GGH activators refer to compounds or molecules that influence the activity or function of the GGH enzyme within cells.
Gamma-glutamyl hydrolase is primarily responsible for the breakdown of glutathione into its constituent amino acids, which include glutamate and cysteine. This enzymatic action is essential for maintaining cellular homeostasis by regulating the levels of glutathione within cells. Glutathione is a vital antioxidant that helps protect cells from oxidative damage and plays a significant role in detoxification processes. GGH activators may modulate the enzyme's activity, affecting the rate at which glutathione is broken down and potentially impacting the cellular levels of this important molecule. Understanding GGH activators is essential for gaining insights into the regulation of cellular redox balance and detoxification mechanisms. The balance of glutathione and its breakdown by GGH are critical for protecting cells from oxidative stress and maintaining overall cellular health. Research into GGH activators can provide valuable information about the fine-tuned control of glutathione metabolism and its implications in various cellular processes, including antioxidant defense and detoxification.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
As a substrate of GGH, high levels of folic acid may upregulate GGH expression to increase folate breakdown and maintain homeostasis. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
As a substrate analog, methotrexate may induce GGH expression as a resistance mechanism in some cancer cells. | ||||||
Pyrimethamine | 58-14-0 | sc-208190 sc-208190A sc-208190B | 1 g 5 g 25 g | $80.00 $238.00 $825.00 | 5 | |
This dihydrofolate reductase inhibitor may increase GGH expression as cells attempt to compensate for folate deficiency. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Known to inhibit folate synthesis, it may indirectly upregulate GGH expression as a compensatory response. | ||||||
Trimethoprim | 738-70-5 | sc-203302 sc-203302A sc-203302B sc-203302C sc-203302D | 5 g 25 g 250 g 1 kg 5 kg | $67.00 $161.00 $255.00 $721.00 $3401.00 | 4 | |
Another inhibitor of dihydrofolate reductase, which could lead to increased GGH expression to maintain folate levels. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
As an antimetabolite that affects folate metabolism, it might upregulate GGH expression in a feedback response. | ||||||
Pemetrexed Disodium | 150399-23-8 | sc-219564 | 10 mg | $136.00 | 5 | |
This antifolate drug may induce GGH expression as part of cellular resistance mechanisms. | ||||||
Folinic acid calcium salt | 1492-18-8 | sc-252837 sc-252837A | 100 mg 500 mg | $94.00 $375.00 | 3 | |
The active form of folinic acid might upregulate GGH as part of cellular mechanisms to regulate folate homeostasis. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
It can modulate gene expression and may affect GGH expression as part of a broad regulatory response. | ||||||
D-(+)-Biotin | 58-85-5 | sc-204706 sc-204706A sc-204706B | 1 g 5 g 25 g | $41.00 $107.00 $333.00 | 1 | |
As a cofactor in carboxylation reactions, biotin may influence GGH expression through complex metabolic interactions. | ||||||