Date published: 2026-4-24

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GCNT3 Inhibitors

GCNT3, or N-acetylglucosaminyltransferase III, is a glycosyltransferase enzyme involved in the biosynthesis of glycoproteins. Specifically, it catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the core 1 O-glycan structure, playing a critical role in glycosylation processes. Glycosylation is a post-translational modification essential for the structural and functional diversity of proteins, influencing various cellular processes such as cell-cell recognition, signaling, and protein stability. GCNT3-mediated glycosylation is particularly important in the context of cell adhesion, migration, and differentiation, as alterations in glycan structures can affect protein interactions and cellular behaviors. Inhibition of GCNT3 can disrupt normal glycosylation patterns, leading to functional consequences within cells. Mechanistically, inhibition may occur through various means, including direct interference with the enzyme's catalytic activity or modulation of upstream signaling pathways regulating GCNT3 expression or activity. Additionally, inhibitors targeting glycosylation pathways may exert their effects by disrupting the availability of substrate molecules or cofactors necessary for GCNT3 function. Consequently, inhibition of GCNT3 can result in aberrant glycoprotein formation, affecting cell adhesion, signaling, and other cellular processes reliant on proper glycosylation. Understanding the mechanisms of GCNT3 inhibition provides insights into potential strategies for modulating glycosylation patterns and their functional outcomes in cellular physiology and disease contexts.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$153.00
$396.00
113
(4)

Staurosporine inhibits GCNT3 by blocking protein kinase C (PKC), an enzyme involved in various cellular processes including signaling pathways that regulate gene expression and protein function.

Swainsonine

72741-87-8sc-201362
sc-201362C
sc-201362A
sc-201362D
sc-201362B
1 mg
2 mg
5 mg
10 mg
25 mg
$138.00
$251.00
$631.00
$815.00
$1832.00
6
(1)

Swainsonine inhibits GCNT3 by disrupting the activity of Golgi α-mannosidase II, an enzyme critical for protein glycosylation, which ultimately affects the function and expression of GCNT3.

Castanospermine

79831-76-8sc-201358
sc-201358A
100 mg
500 mg
$184.00
$632.00
10
(1)

Castanospermine inhibits GCNT3 by interfering with the function of α-glucosidase I, an enzyme involved in N-linked glycosylation, which impacts the processing and activity of GCNT3.

Benzyl-2-acetamido-2-deoxy-α-D-galactopyranoside

3554-93-6sc-203427
sc-203427A
100 mg
1 g
$350.00
$3184.00
2
(0)

Benzyl α-GalNAc inhibits GCNT3 by competitively binding to the enzyme's active site, preventing the attachment of galactose to glycoproteins and thereby hindering the activity of GCNT3.

Kifunensine

109944-15-2sc-201364
sc-201364A
sc-201364B
sc-201364C
1 mg
5 mg
10 mg
100 mg
$135.00
$540.00
$1025.00
$6248.00
25
(2)

Kifunensine inhibits GCNT3 by inhibiting α-mannosidase I, a key enzyme in N-linked glycosylation, leading to abnormal glycosylation patterns that interfere with GCNT3 function.

Tunicamycin

11089-65-9sc-3506A
sc-3506
5 mg
10 mg
$172.00
$305.00
66
(3)

Tunicamycin inhibits GCNT3 by blocking the synthesis of N-linked glycoproteins, disrupting the proper folding and processing of glycoproteins, which indirectly affects the function of GCNT3.

2-Deoxy-D-glucose

154-17-6sc-202010
sc-202010A
1 g
5 g
$70.00
$215.00
26
(2)

2-Deoxy-D-glucose inhibits GCNT3 by competitively inhibiting glucose uptake, leading to decreased availability of substrates required for glycosylation, which impairs GCNT3 activity.

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$31.00
$53.00
$124.00
$374.00
25
(3)

Brefeldin A inhibits GCNT3 by disrupting protein trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus, interfering with glycosylation processes essential for GCNT3 function.

Deoxynojirimycin

19130-96-2sc-201369
sc-201369A
1 mg
5 mg
$73.00
$145.00
(0)

1-Deoxynojirimycin inhibits GCNT3 by inhibiting α-glucosidase II, an enzyme required for N-linked glycosylation, leading to aberrant glycoprotein processing and impaired GCNT3 function.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$136.00
$446.00
114
(2)

Thapsigargin inhibits GCNT3 by disrupting calcium homeostasis and inducing ER stress, leading to dysfunction of glycosylation processes that are essential for GCNT3 activity and expression.