GCNF Inhibitors
GCNF inhibitors are chemical compounds that inhibit Germ Cell Nuclear Factor (GCNF), a nuclear receptor that plays a crucial role in cell differentiation and development. GCNF, also known as NR6A1 (Nuclear Receptor Subfamily 6 Group A Member 1), is primarily involved in the regulation of gene expression during embryonic development and in adult tissues. The function of GCNF in the regulation of gene transcription makes it an important target for these specialized inhibitors.
GCNF inhibitors are structured to interact selectively with the GCNF receptor, particularly at its DNA-binding domain or ligand-binding domain, thereby modulating its transcriptional activity. These inhibitors mimic or compete with the natural ligands of GCNF or interferes with its ability to bind to DNA. This includes specific functional groups and structural motifs that ensure effective and selective binding to the receptor. These functional groups may include hydrogen bond donors or acceptors, hydrophobic chains, and various ring structures, all orchestrated to fit into the active sites of GCNF.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
A synthetic glucocorticoid that can modulate transcription factor activity, possibly affecting GCNF gene expression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
A diterpene triepoxide that may influence transcription and inhibit RNA polymerase II activity, potentially affecting GCNF expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
An inhibitor of histone deacetylase (HDAC) that can alter chromatin structure and gene expression, possibly including GCNF. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that could demethylate DNA and reactivate silenced genes, potentially affecting GCNF expression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
An inhibitor of DNA topoisomerase II that could disrupt DNA replication and transcription, potentially affecting GCNF expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Interacts with DNA and inhibits RNA synthesis, which could downregulate GCNF expression. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Stabilizes microtubules and can block cell cycle progression, potentially affecting GCNF expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
An inhibitor of DNA topoisomerase I, which could impact DNA replication and transcription, including that of GCNF. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Forms DNA adducts that can inhibit transcription and possibly affect GCNF expression. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Inhibits ribonucleotide reductase, which might influence DNA synthesis and repair mechanisms, potentially affecting GCNF expression. | ||||||