GCNF Activators
GCNF, or germ cell nuclear factor, is a member of the nuclear receptor superfamily and functions as a transcriptional repressor involved in gene regulation during embryonic development and in the maintenance of embryonic stem cell pluripotency. GCNF activators, therefore, are chemical compounds that can influence the activity of GCNF by modulating its ability to bind to DNA and regulate gene expression. These activators typically exert their effects by inducing conformational changes in the GCNF protein structure, thereby affecting its interaction with co-repressors and co-activators. The regulation of GCNF activity is complex and can be influenced by various signaling pathways within the cell, often involving changes in post-translational modifications of the protein or alterations in the cellular concentrations of cofactors that modulate its activity.
These compounds may interact directly with the ligand-binding domain of GCNF, initiating a cascade of intracellular events that lead to changes in the transcriptional repression activity of GCNF. This specific interaction is crucial, as it dictates the precise modulation of the target genes by GCNF and, consequently, the downstream biological processes. The actions of these activators are typically observed at the genomic level, where changes in the expression patterns of genes under the control of GCNF are seen.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid binds to retinoic acid receptors, which can heterodimerize with GCNF, potentially enhancing GCNF's role in the regulation of gene expression during embryonic development and in adult tissues. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
Cholesterol serves as a precursor for the biosynthesis of steroid hormones, which can influence GCNF activation due to its role in the regulatory networks of lipid and steroid metabolism. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which could lead to the phosphorylation of proteins involved in the signaling pathways that GCNF participates in, such as metabolic regulation and differentiation processes. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $71.00 $424.00 $3121.00 $5722.00 $148.00 | 10 | |
9-cis-retinoic acid is a high affinity ligand for retinoid X receptors which can form heterodimers with GCNF, potentially enhancing its regulatory effects on gene transcription. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, which is involved in Wnt signaling. Inhibition of GSK-3 could lead to changes in the transcriptional regulation activities in which GCNF is involved, specifically in the context of development and cell differentiation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cAMP analog that activates PKA, which could then phosphorylate transcriptional machinery components, possibly enhancing GCNF's activity in gene regulation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the PI3K/Akt signaling pathway, which is connected to metabolic regulation. This activation can have downstream effects that may enhance GCNF activity in the context of metabolic processes. | ||||||
25-Hydroxycholesterol | 2140-46-7 | sc-214091B sc-214091 sc-214091A sc-214091C | 5 mg 10 mg 25 mg 100 mg | $53.00 $91.00 $169.00 $474.00 | 8 | |
25-hydroxycholesterol is involved in cholesterol metabolism and regulation. Its presence could enhance GCNF activity, as GCNF is implicated in the transcriptional regulation of metabolic genes. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone is a PPARγ agonist that can modulate lipid metabolism and insulin sensitivity, pathways where GCNF is potentially involved in transcriptional regulation. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 through its active metabolite, calcitriol, can influence calcium and phosphorus homeostasis. It may interact with pathways involving GCNF due to GCNF's role in metabolic regulation. | ||||||