GASP-2 Activators
GASP-2 Activators, by their nomenclature, suggest a role in modulating the activity of a molecular entity referred to as GASP-2. In the context of biochemistry, activators are often compounds that enhance the function or activity of a specific target molecule. GASP-2 could be a protein, enzyme, or signaling molecule, and the activators associated with it may play a crucial role in regulating its biological effects.
These activators might function by binding to GASP-2 and inducing conformational changes that enhance its activity or facilitate its interaction with other cellular components. The specificity of GASP-2 Activators suggests a sophisticated level of molecular recognition, where these compounds likely possess structural features that enable them to selectively interact with GASP-2. Understanding the mechanism of action and the molecular details of these activators could provide valuable insights into the normal physiological regulation of GASP-2 and potential implications for related cellular processes. Further research would be necessary to elucidate the specific biochemical pathways and functions associated with GASP-2 and its activators, shedding light on the intricacies of cellular signaling and molecular interactions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an adenylate cyclase activator, which leads to an increase in cyclic AMP (cAMP) levels, in turn activating protein kinase A (PKA). PKA then phosphorylates target proteins, which may enhance GASP-2 by promoting its functional conformation or stabilization within cellular compartments that facilitate its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which phosphorylates serine and threonine residues on many cellular proteins. Phosphorylation by PKC can lead to enhanced GASP-2 activity if GASP-2 is among the substrate proteins directly or if the phosphorylation of associated regulatory proteins leads to a conformational change that favors GASP-2 activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calmodulin and calcium/calmodulin-dependent protein kinases (CaMKs). These kinases could enhance GASP-2 function through direct phosphorylation or by phosphorylating associated proteins that regulate GASP-2's activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can inhibit certain types of methyltransferases, which could lead to reduced methylation of proteins or nucleic acids. If GASP-2 activity is modulated by methylation, EGCG could enhance its function by maintaining a less methylated and more active state. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $73.00 $112.00 $367.00 | 18 | |
SNAP releases nitric oxide (NO), which can stimulate soluble guanylate cyclase to produce cGMP. Increased cGMP can activate protein kinase G (PKG), potentially leading to the phosphorylation of proteins that regulate GASP-2 activity or directly enhancing GASP-2's activity through phosphorylation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels via G protein-coupled receptor signaling, leading to PKA activation. PKA can then enhance GASP-2 function directly through phosphorylation or indirectly by phosphorylating regulatory proteins associated with GASP-2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which can lead to altered AKT signaling. This alteration in signaling may lead to changes in downstream proteins that regulate GASP-2 function, resulting in its enhanced activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. Inhibition of p38 MAPK can result in the upregulation of alternative pathways or feedback loops that may indirectly enhance GASP-2's activity through compensatory mechanisms within the cell. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which acts upstream of ERK MAPK. Inhibition of MEK can result in compensatory cellular responses that could lead to the enhancement of GASP-2 activity through alternative signaling pathways. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an activator of AMP-activated protein kinase (AMPK). Activation of AMPK can lead to phosphorylation of downstream substrates that could enhance GASP-2 function if GASP-2 is among these substrates or if it is regulated by them. | ||||||