Gas7 Activators
Gas7 Activators belong to a distinctive chemical class characterized by their ability to modulate the activity of Growth Arrest-Specific 7 (Gas7) protein. Gas7 is a multifunctional protein implicated in diverse cellular processes, including cytoskeletal organization, cell morphology, and intracellular signaling. The small molecules identified as Gas7 Activators interact with Gas7 and influence its functional dynamics, thereby regulating downstream cellular events. This chemical class exhibits a unique mechanism of action by specifically targeting Gas7, a protein that plays a crucial role in cellular homeostasis and cytoskeletal architecture.
Structurally, Gas7 Activators typically feature distinct chemical moieties that enable binding to specific domains within the Gas7 protein. This interaction induces conformational changes in Gas7, resulting in altered cellular responses. The modulation of Gas7 activity by these activators represents a novel avenue for manipulating cellular processes dependent on Gas7 function. The elucidation of the molecular details of Gas7 activation by these compounds provides valuable insights into the intricate regulation of cellular dynamics and may pave the way for the development of novel tools for studying cellular physiology. The chemical class of Gas7 Activators thus emerges as a promising area of research, contributing to our understanding of the intricacies of cellular regulation at the molecular level.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, a compound found in the root of the Coleus forskohlii plant, is a potent activator of the enzyme adenylyl cyclase, which increases the production of cyclic AMP (cAMP), a second messenger in cells. By increasing cAMP levels, Forskolin can enhance the downstream signaling of proteins that are regulated by cAMP, such as Protein Kinase A (PKA), which can then phosphorylate and enhance the activity of Gas7. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC), which can phosphorylate a plethora of target proteins, including Gas7. PKC activation leads to increased phosphorylation of Gas7, enhancing its functional activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent and selective inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). By inhibiting these phosphatases, Okadaic Acid can enhance the phosphorylation state of proteins, including Gas7, thereby increasing their functional activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. Increased PKA activity can lead to the phosphorylation and activation of Gas7. | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $133.00 | 20 | |
KN-62 is a potent and selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). Inhibition of CaMKII can enhance the activity of Gas7 by decreasing competition for shared substrates or docking sites. | ||||||
Zardaverine | 101975-10-4 | sc-201208 sc-201208A | 5 mg 25 mg | $88.00 $379.00 | 1 | |
Zardaverine is a selective inhibitor of cAMP and cGMP phosphodiesterases. Inhibition of these enzymes increases the intracellular levels of cAMP and cGMP, enhancing the activities of PKA and PKG, respectively. Increased PKA/PKG activities can enhance Gas7 function. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $60.00 $192.00 $272.00 $883.00 | 1 | |
Spermine is a polyamine that can enhance the activity of Gas7 by increasing the sensitivity of Gas7 to intracellular calcium levels. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4). By inhibiting PDE4, Rolipram increases intracellular cAMP levels, which can enhance the activity of Gas7 via PKA activation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a plant flavonoid, can inhibit protein tyrosine phosphatase, enhancing the phosphorylation and thus activation of proteins like Gas7. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, leading to increased intracellular cAMP levels. This can enhance the activity of Gas7 via the activation of PKA. | ||||||