Date published: 2026-1-25

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Ganglioside GD2 Inhibitors

Ganglioside GD2 is a glycosphingolipid predominantly expressed on the surface of neuroectoderm-derived tissues, particularly in neuronal cells and certain tumors, making it a promising target for intervention. Functionally, Ganglioside GD2 plays a crucial role in cell-cell recognition, adhesion, and signaling, contributing to various physiological processes such as neuronal development, cell differentiation, and immune response modulation. Moreover, Ganglioside GD2 has been implicated in promoting tumor growth, metastasis, and resistance to apoptosis in cancer cells, highlighting its significance as a target in oncology. Inhibition of Ganglioside GD2 can be achieved through various mechanisms, primarily targeting its biosynthesis, expression, or downstream signaling pathways. One approach involves blocking the enzymatic processes involved in Ganglioside GD2 synthesis, such as inhibiting the enzymes responsible for glycosylation or sialylation of precursor molecules. Additionally, inhibition of Ganglioside GD2 expression can be accomplished by disrupting the transcriptional regulation of genes involved in Ganglioside GD2 biosynthesis or by promoting its degradation through lysosomal or proteasomal pathways. Furthermore, targeting signaling pathways associated with Ganglioside GD2-mediated cellular functions, such as growth factor receptors or downstream effectors like MAPK and PI3K/AKT, can also effectively inhibit its activity. Overall, inhibition of Ganglioside GD2 represents a promising strategy for intervention in various pathological conditions, particularly in cancer, by targeting its key roles in cell signaling and tumorigenesis.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic acid influences cell differentiation and proliferation. It has been observed to downregulate GD2 expression in certain cell types, possibly through modulation of gene expression.

Disulfiram

97-77-8sc-205654
sc-205654A
50 g
100 g
$53.00
$89.00
7
(1)

Disulfiram has been shown to inhibit the synthesis of GD2 in neuroblastoma cells. Its mechanism may involve disruption of lipid metabolism or direct inhibition of GD2 synthase.

4-Hydroxyphenylretinamide

65646-68-6sc-200900
sc-200900A
5 mg
25 mg
$104.00
$315.00
(0)

4-Hydroxyphenylretinamide, a synthetic retinoid, has been observed to reduce GD2 expression in neuroblastoma cells. It may act by altering retinoid signaling pathways involved in cell differentiation.

D-threo-PDMP

109836-82-0sc-280659
10 mg
$808.00
1
(0)

D-PDMP is a glucosylceramide synthase inhibitor that has been shown to reduce GD2 levels in cells. It interferes with the biosynthesis of glycosphingolipids, including GD2.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$45.00
$164.00
$200.00
$402.00
$575.00
$981.00
$2031.00
46
(1)

Genistein, a soy isoflavone, has been reported to decrease GD2 expression in neuroblastoma cells. It may modulate signaling pathways and gene expression involved in GD2 synthesis.

Betulinic Acid

472-15-1sc-200132
sc-200132A
25 mg
100 mg
$117.00
$344.00
3
(1)

Betulinic acid is a triterpenoid that has been found to downregulate GD2 expression in melanoma cells. It may influence apoptotic pathways and cellular differentiation.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin, the active compound in turmeric, has been shown to decrease GD2 expression in certain cancer cells. Its mechanism may involve anti-inflammatory and antioxidant effects.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol, a polyphenol found in grapes, has demonstrated the ability to reduce GD2 levels in neuroblastoma cells. It may act through modulation of survival and apoptotic pathways.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

Quercetin, a flavonoid found in many plants, has been reported to decrease GD2 expression in certain cell types. Its mechanism may involve anti-inflammatory and antioxidant activities.

Indomethacin

53-86-1sc-200503
sc-200503A
1 g
5 g
$29.00
$38.00
18
(1)

Indomethacin, a nonsteroidal anti-inflammatory drug, has been found to reduce GD2 levels in neuroblastoma cells. It may act by inhibiting enzymes involved in lipid metabolism.