γ-crystallin Activators
γ-crystallin Activators are a class of chemicals that can enhance the functional activity of γ-crystallin through various specific biochemical or cellular pathways. They consist of a diverse array of compounds such as Epigallocatechin gallate, Curcumin, Resveratrol, Quercetin, Retinoic acid, N-acetylcysteine, Sulforaphane, Berberine, Metformin, Salicylic acid, Capsaicin, and Lycopene. These compounds can act on several different pathways, including PI3K/AKT, Nrf2, SIRT1, AMPK, RAR and RXR nuclear receptors, NRF2, NF-κB, TRPV1, and PPAR-γ.
For example, Epigallocatechin gallate and Resveratrol activate the PI3K/AKT and SIRT1 pathways respectively, leading to the enhancement of γ-crystallin functionality. Similarly, Curcumin and N-acetylcysteine activate the Nrf2 pathway, altering the oxidative stress in the cellular environment and enhancing γ-crystallin functionality. Quercetin, Berberine, and Metformin activate the AMPK pathway, leading to improved cellular energy availability and thus enhanced γ-crystallin function. Retinoic acid impacts γ-crystallin functionality by activating the RAR and RXR nuclear receptors and altering its post-translational modifications. Sulforaphane, like Curcumin and N-acetylcysteine, activates the Nrf2 pathway and enhances γ-crystallin function by reducing oxidative stress.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate is a catechin, mainly found in green tea. It is known to activate the PI3K/AKT pathway. Since γ-crystallin is an AKT substrate, the activation of AKT can lead to the enhanced functional activity of γ-crystallin. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural compound found in turmeric and is known to activate the Nrf2 pathway. This pathway can influence the functionality of γ-crystallin by modulating oxidative stress in the cellular environment. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol found in grapes and berries, activates SIRT1. SIRT1 can enhance the functional activity of γ-crystallin through deacetylation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid and can activate the AMPK pathway. The AMPK pathway can enhance the functionality of γ-crystallin by increasing energy availability in cells. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of Vitamin A, can activate the RAR and RXR nuclear receptors, which can impact γ-crystallin functionality by altering its post-translational modifications. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-acetylcysteine is a precursor to glutathione and can activate the NRF2 pathway. Activation of NRF2 can lead to the enhanced functional activity of γ-crystallin by decreasing oxidative stress. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is an isothiocyanate found in cruciferous vegetables that activates the Nrf2 pathway, which can lead to the enhanced functional activity of γ-crystallin by altering the cellular oxidative environment. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine is a plant alkaloid that activates AMPK. Enhanced AMPK activity can lead to the functional enhancement of γ-crystallin by increasing cellular energy availability. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin is an antidiabetic agent that activates AMPK. The AMPK pathway can enhance γ-crystallin functionality by regulating cellular energy homeostasis. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $47.00 $94.00 $119.00 | 3 | |
Salicylic acid activates NF-κB pathway. This activation can enhance the functional activity of γ-crystallin by altering the cellular inflammatory environment. | ||||||