GalNAc-TL4 Activators
GalNAc-TL4 include a variety of substances, each contributing to the activation process in distinct ways. Manganese (II) chloride is one such activator, enhancing the enzymatic glycosylation activity of GalNAc-TL4 by serving as an essential cofactor for the enzyme. Similarly, magnesium chloride and calcium chloride contribute to the activation of GalNAc-TL4 by acting as cofactors, with magnesium ions influencing the enzyme's structure and catalytic efficiency, and calcium ions stabilizing the protein structure to maintain an active conformation. Zinc chloride and cobalt(II) chloride also play roles as metal ion cofactors, with zinc ions potentially acting as structural or catalytic enhancers and cobalt ions necessary for full catalytic activity. Nickel(II) chloride's activation mechanism may involve inducing conformational changes in GalNAc-TL4 or participating directly in the catalysis of the glycosylation reaction.
Other chemical compounds facilitate the activation of GalNAc-TL4. Uridine diphosphate (UDP) is fundamental, providing the glycosyl donor in enzymatic reactions to enable the transfer of sugar moieties. The presence of N-Acetylgalactosamine is also crucial as it serves as the specific substrate that GalNAc-TL4 uses during glycosylation. Sodium fluoride acts as an activator by maintaining the enzyme in a phosphorylated state, inhibiting phosphatases that could otherwise dephosphorylate and deactivate the enzyme. Copper(II) sulfate may enhance the structural stability of GalNAc-TL4 or participate in its catalytic process. Sodium acetate's role in activation may involve the provision of acetate ions for post-translational modifications that can increase enzyme activity. Lastly, potassium chloride can optimize the enzyme's conformation and function by affecting the ionic strength and electrostatic environment around GalNAc-TL4. Each of these chemicals, through their specific mechanisms, contributes to the effective activation of GalNAc-TL4, ensuring its role in glycosylation is carried out efficiently.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $30.00 | ||
Manganese (II) chloride can activate the GalNAc-TL4 protein by enhancing its enzymatic glycosylation activity. Manganese ions are essential cofactors for glycosyltransferases, and their presence is critical for the catalytic function of these enzymes. | ||||||
Uridine 5′-diphosphate sodium salt | 21931-53-3 | sc-222401 sc-222401A | 25 mg 100 mg | $37.00 $77.00 | ||
Uridine diphosphate serves as a glycosyl donor in enzymatic reactions catalyzed by glycosyltransferases like GalNAc-TL4. The availability of UDP is directly related to the functional activation of glycosyltransferase activity. | ||||||
N-Acetyl-D-galactosamine | 1811-31-0 | sc-221979 sc-221979A sc-221979C sc-221979B sc-221979D | 10 mg 100 mg 1 g 5 g 50 g | $50.00 $75.00 $262.00 $1020.00 $1300.00 | ||
N-Acetylgalactosamine is a monosaccharide that acts as a substrate for GalNAc-TL4 in the glycosylation process. Providing this specific sugar directly supports the functional role of the enzyme in transferring GalNAc to proteins. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
Calcium chloride can activate the GalNAc-TL4 by stabilizing the protein structure and maintaining the enzyme in an active conformation. Calcium ions are known to play a role in the regulation of many enzymes, including glycosyltransferases. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Magnesium chloride can activate GalNAc-TL4 by serving as a cofactor that is essential for the enzyme's glycosylation activity. Magnesium ions can influence the enzyme's structure and catalytic efficiency. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $39.00 $45.00 $98.00 | 26 | |
Sodium fluoride can activate GalNAc-TL4 by inhibiting phosphatases that may dephosphorylate the protein, thus maintaining it in a phosphorylated, active state. Glycosyltransferases can be regulated by phosphorylation status. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc chloride can activate GalNAc-TL4 as zinc ions may act as structural or catalytic cofactors for glycosyltransferases, thereby enhancing the enzyme's ability to catalyze the transfer of sugar moieties to acceptor molecules. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $63.00 $173.00 | 7 | |
Cobalt(II) chloride can activate the GalNAc-TL4 protein by acting as a metal cofactor that is required for the full catalytic activity of many glycosyltransferases, potentially including GalNAc-TL4. | ||||||
Nickel(II) chloride | 7718-54-9 | sc-236169 sc-236169A | 100 g 500 g | $67.00 $184.00 | ||
Nickel(II) chloride may activate GalNAc-TL4 by serving as a metal ion cofactor that can induce conformational changes in the enzyme or participate directly in the catalysis of the glycosylation reaction. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper(II) sulfate can activate GalNAc-TL4 by potentially serving as a metal ion cofactor that enhances the structural stability of the enzyme or participates in the catalytic process of glycosyltransferases. | ||||||