GAGE12F Inhibitors
GAGE12F inhibitors are chemical compounds that target and inhibit the activity of the GAGE12F protein, a member of the GAGE protein family. GAGE proteins belong to a group of cancer/testis antigens (CTAs) that are normally expressed in reproductive tissues but can also be aberrantly expressed in other types of cells under specific conditions. GAGE12F shares structural and functional characteristics with other members of the GAGE family, and its inhibition involves binding to key functional sites on the protein, thereby interfering with its role in cellular processes. GAGE proteins are known for their involvement in various molecular pathways, including those related to cellular survival, proliferation, and stress responses, and their inhibition can lead to altered cellular behavior.
The structural features of GAGE12F inhibitors typically involve small-molecule designs optimized for high specificity and affinity toward GAGE12F. These inhibitors may exploit key motifs within the protein's structure to achieve selective binding, potentially interacting with hydrophobic pockets or essential residues necessary for GAGE12F's function. By disrupting the protein's activity, GAGE12F inhibitors may lead to modulation of the molecular pathways in which GAGE12F is involved. The development of these inhibitors often includes structure-activity relationship (SAR) studies to refine their binding properties, stability, and overall efficacy in biochemical settings.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules and thereby inhibits the disassembly of microtubules, G antigen 12F relies on the appropriate formation and disassembly of microtubules for its intracellular trafficking and function. The stabilization of microtubules can disrupt the cellular localization and function of G antigen 12F. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin, inhibiting microtubule formation, which is essential for cell division. By disrupting microtubule dynamics, it can interfere with the cellular processes that depend on cytoskeletal changes, such as the function of G antigen 12F. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, preventing its polymerization and the formation of microtubules. This action can inhibit the proper functioning of G antigen 12F, which is dependent on microtubule-mediated processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which are involved in signaling pathways that regulate various cellular functions. Inhibition of PI3K can lead to the downregulation of cellular processes that are necessary for G antigen 12F activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 is a inhibitor of PI3K. It can inhibit signaling pathways that modulate the function of G antigen 12F, leading to its functional inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is involved in cell growth and proliferation. As mTOR can regulate protein synthesis and other cellular processes, its inhibition can disrupt the functional activity of G antigen 12F. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 selectively inhibits MEK, which is involved in the MAPK/ERK pathway. The MAPK/ERK pathway is known to regulate various cellular functions, and its inhibition can lead to the functional inhibition of G antigen 12F. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 also inhibits MEK, blocking the MAPK/ERK pathway and potentially disrupting the function of G antigen 12F that relies on this pathway for its activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 is a specific inhibitor of p38 MAP kinase, which is part of the MAPK pathway. By inhibiting p38 MAP kinase, it can disrupt signaling that modulates the function of G antigen 12F, leading to its inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, which is part of the MAPK pathway. Inhibition of JNK can affect the signaling required for the proper function of G antigen 12F, leading to its inhibition. | ||||||