GABARAP Inhibitors
GABARAP inhibitors are a class of chemical compounds specifically designed to target and inhibit the function of GABA type A receptor-associated protein (GABARAP), a member of the Atg8 family of proteins. GABARAP plays a crucial role in autophagy, a cellular process responsible for the degradation and recycling of damaged organelles, proteins, and other cellular components. As part of the autophagy machinery, GABARAP is involved in the elongation and closure of autophagosomes, which are double-membraned vesicles that engulf cellular debris. GABARAP also plays a significant role in the trafficking and membrane fusion events required for the maturation of autophagosomes and their eventual fusion with lysosomes, where the enclosed material is degraded. By inhibiting GABARAP, researchers can disrupt autophagic processes, providing a tool to study the specific contributions of GABARAP to autophagy and related cellular functions.
In research, GABARAP inhibitors are valuable tools for exploring the intricate mechanisms of autophagy and understanding the role of GABARAP in this essential cellular process. By blocking GABARAP activity, scientists can investigate how the inhibition affects the formation, maturation, and function of autophagosomes, shedding light on the broader implications of disrupted autophagy on cellular homeostasis. These inhibitors also allow researchers to explore the interactions between GABARAP and other autophagy-related proteins, as well as its involvement in processes such as membrane trafficking, intracellular signaling, and cellular stress responses. Additionally, GABARAP inhibitors can be used to study the impact of autophagy inhibition on various cellular processes, including cell survival, metabolism, and the degradation of specific cellular components. Through these studies, the use of GABARAP inhibitors enhances our understanding of the molecular mechanisms underlying autophagy, the specific role of GABARAP in autophagosome dynamics, and the broader significance of autophagy in maintaining cellular function and integrity across various biological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-MA inhibits early stages of autophagy by blocking class III PI3K. This inhibition can indirectly affect GABARAP activity by hindering the autophagic process. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is an inhibitor of PI3K, affecting autophagy initiation. By inhibiting PI3K, Wortmannin can indirectly reduce GABARAP activity by impairing the autophagic process. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, another PI3K inhibitor, can also hinder the initiation of autophagy, potentially leading to reduced GABARAP activity. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 inhibits the fusion between autophagosomes and lysosomes, a key step in autophagy. This inhibition can indirectly reduce GABARAP activity by disrupting the autophagic process. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine inhibits autophagosome-lysosome fusion, leading to an accumulation of autophagic vacuoles. This inhibition might indirectly reduce GABARAP activity by disrupting the autophagic process. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Similar to Chloroquine, Hydroxychloroquine inhibits autophagosome-lysosome fusion. Its action can indirectly reduce GABARAP activity by impairing the completion of the autophagic process. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine disrupts microtubule formation, which can indirectly affect autophagy and thus reduce GABARAP activity, as microtubules are important for the transport of autophagosomes. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules, and this stabilization can disrupt autophagosome movement and fusion with lysosomes, potentially reducing GABARAP activity. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
Spautin-1 is known to inhibit autophagy by targeting ubiquitin-specific peptidases involved in autophagosome maturation. This inhibition could indirectly reduce GABARAP activity. | ||||||
SAR405 | 1523406-39-4 | sc-507416 | 1 mg | $125.00 | ||
SAR405 inhibits Vps34, a class III PI3K, disrupting autophagosome formation. This inhibition can lead to reduced GABARAP activity as Vps34 is involved in the initiation of autophagy. | ||||||