G2E3 Activators
G2E3, a ubiquitin-protein ligase, plays a pivotal role in the regulation of cell cycle progression, DNA repair mechanisms, and the response to cellular stress. Its activity is crucial for maintaining genomic stability and orchestrating a proper response to DNA damage. The protein's ability to target specific substrates for ubiquitination and subsequent proteasomal degradation underscores its significance in controlling the cell cycle and ensuring the integrity of the genomic material. Activation of G2E3 is a finely tuned process that involves intricate signaling pathways, highlighting the complexity of its regulation and the importance of its activity in cellular homeostasis.
The mechanisms of G2E3 activation are multifaceted and involve direct and indirect interactions with various biochemical pathways. Indirect activators influence G2E3's function by modulating the activity of kinases, phosphatases, and other regulatory molecules that can alter the phosphorylation state, localization, and protein-protein interactions of G2E3. These activators, through their impact on signaling cascades such as the cAMP/PKA pathway, AMPK, PKC, and sirtuin-mediated pathways, contribute to the regulation of G2E3's activity in response to cellular signals and stress conditions. The intricate network of pathways underscores the complexity of G2E3's activation and the potential for various chemicals to influence its function indirectly. Understanding these processes is crucial for unraveling the regulatory mechanisms governing G2E3's role in cellular physiology and its potential implications in disease states.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels, which can indirectly activate G2E3 by enhancing the cAMP-dependent protein kinase A (PKA) pathway. PKA then phosphorylates target proteins that may include regulatory factors influencing G2E3 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX, a nonspecific inhibitor of phosphodiesterases, prevents cAMP breakdown, thereby sustaining PKA activity. Prolonged PKA activation can indirectly support G2E3 activation through phosphorylation of proteins that interact with or regulate G2E3, enhancing its functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can lead to the activation of pathways that indirectly enhance G2E3 activity. PKC-mediated signaling may modify the phosphorylation state of proteins that regulate G2E3's stability or activity, thus facilitating its functional activation. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR stimulates AMP-activated protein kinase (AMPK) activation, which can indirectly influence G2E3 by altering energy balance and phosphorylation patterns within the cell. This may lead to the activation of pathways that enhance G2E3's role in cellular stress responses. | ||||||
WP1130 | 856243-80-6 | sc-364650 sc-364650A | 10 mg 50 mg | $480.00 $1455.00 | 1 | |
WP1130 is a small molecule that inhibits several deubiquitinase (DUB) enzymes, including proteasome-associated DUBs. Inhibition of DUBs by WP1130 leads to the accumulation of ubiquitinated proteins, increasing their targeting for proteasomal degradation such as G2E3. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $39.00 $45.00 $98.00 | 26 | |
Sodium fluoride acts as a nonspecific activator of several kinases, potentially leading to the phosphorylation and activation of proteins within pathways that G2E3 is part of, thereby indirectly enhancing G2E3 activation through post-translational modifications. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, through its antioxidant properties, can modulate signaling pathways related to oxidative stress and thus might indirectly activate G2E3 by influencing the cellular response to oxidative damage, potentially enhancing G2E3's role in DNA repair mechanisms. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuin pathways, which are involved in cellular stress responses and longevity. Through sirtuin activation, it could indirectly enhance G2E3's function in DNA damage response and cell cycle regulation by modulating the acetylation status of proteins interacting with G2E3. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin influences multiple signaling pathways, including NF-κB, which could indirectly activate G2E3 by modulating inflammatory responses and cellular stress pathways, potentially enhancing G2E3's involvement in genomic stability and stress response mechanisms. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin activates AMPK, similarly to AICAR, and could indirectly activate G2E3 by influencing cellular metabolism and energy homeostasis, which may affect pathways involving G2E3, particularly in response to metabolic stress. | ||||||