fzr Activators
The fzr Activators represent a diverse group of chemicals that exert their influence on fzr, a crucial protein involved in cell cycle regulation. One prominent member is Apcin, a small molecule inhibitor of the APC complex. Apcin indirectly activates fzr by impeding the ubiquitination and degradation of fzr, thereby enhancing its cellular levels and promoting cell cycle progression. Similarly, MLN4924, a NEDD8-activating enzyme (NAE) inhibitor, disrupts neddylation of cullin-based ubiquitin ligases, indirectly stabilizing fzr and enhancing its activity.
Furthermore, JNK Inhibitor VIII demonstrates indirect activation of fzr by suppressing the JNK pathway, which negatively regulates fzr expression. This inhibition leads to an upregulation of fzr expression and increased fzr activity, contributing to proper cell cycle control. These fzr Activators also include compounds like Curcumin and Rapamycin, which modulate the Wnt signaling pathway and mTOR, respectively. Curcumin inhibits Wnt activation, indirectly promoting fzr activation by downregulating fzr inhibitors, while Rapamycin inhibits mTOR, a negative regulator of fzr, resulting in increased fzr expression and activity. The fzr Activators collectively illustrate a strategic approach to modulating fzr activity by influencing various signaling pathways and cellular processes. These chemicals provide valuable tools for researchers seeking to unravel the intricate mechanisms governing cell cycle progression.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
MLN4924, an NEDD8-activating enzyme (NAE) inhibitor, indirectly activates fzr by inhibiting the neddylation of cullin-based ubiquitin ligases. This disruption enhances fzr stability and activity. | ||||||
JNK Inhibitor VIII | 894804-07-0 | sc-202673 | 5 mg | $267.00 | 2 | |
JNK Inhibitor VIII indirectly activates fzr by inhibiting the JNK pathway, which negatively regulates fzr expression. The inhibition of JNK leads to increased fzr expression and enhanced fzr activity. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB-216763, a GSK-3 inhibitor, indirectly activates fzr by inhibiting GSK-3, which phosphorylates fzr and targets it for degradation. Inhibition of GSK-3 leads to increased fzr stability and activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, indirectly activates fzr by inhibiting the PI3K/Akt pathway, which negatively regulates fzr expression. Inhibition of PI3K results in increased fzr expression and activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin indirectly activates fzr by modulating the Wnt signaling pathway. It inhibits Wnt activation, leading to the downregulation of fzr inhibitors and subsequent activation of fzr. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin indirectly activates fzr by inhibiting mTOR, a negative regulator of fzr. Inhibition of mTOR results in increased fzr expression and activity, promoting cell cycle regulation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187, a calcium ionophore, indirectly activates fzr by modulating intracellular calcium levels. This influences calcium-dependent signaling pathways, ultimately leading to fzr activation. | ||||||
TPEN | 16858-02-9 | sc-200131 | 100 mg | $127.00 | 10 | |
TPEN, a metal chelator, indirectly activates fzr by influencing metal-dependent signaling pathways. Chelation of metals affects fzr regulators, leading to increased fzr stability and activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAPK inhibitor, indirectly activates fzr by inhibiting the p38 MAPK pathway. Inhibition of p38 MAPK negatively regulates fzr, resulting in increased fzr expression and activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol indirectly activates fzr by modulating the SIRT1 pathway. It activates SIRT1, which in turn deacetylates and stabilizes fzr. This promotes fzr activity and cell cycle regulation. | ||||||