FSH Inhibitors
Follicle-stimulating hormone (FSH) inhibitors are a class of chemical compounds that specifically target and inhibit the action of FSH, a glycoprotein hormone produced by the anterior pituitary gland. FSH plays a crucial role in the regulation of reproductive processes, particularly in the development of ovarian follicles in females and spermatogenesis in males. FSH inhibitors exert their action by interfering with the binding of FSH to its receptors on target cells, thereby reducing or halting the downstream signaling pathways that are responsible for the hormonal regulation of reproductive tissues. These compounds can be structurally diverse, including both small molecules and larger biological inhibitors, which can block FSH activity through various mechanisms, such as competitive antagonism or allosteric modulation.
The inhibition of FSH function results in the suppression of signaling pathways involved in cell proliferation, differentiation, and the production of hormones such as estrogen in females and testosterone in males. By blocking FSH, these inhibitors can modulate the feedback loops that maintain the balance of reproductive hormones. Chemically, FSH inhibitors may target the interaction sites between the hormone and its receptor or affect the receptor's ability to transduce signals within the cell. Some compounds are designed to mimic natural regulatory mechanisms, while others are engineered to bind directly to FSH or its receptor, preventing the formation of the hormone-receptor complex. Their structures are often designed to achieve high specificity and potency, making them a valuable tool for studying reproductive physiology and cellular signaling pathways related to FSH.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol can decrease FSH expression by engaging estrogen receptors in the hypothalamus and pituitary, triggering a feedback reduction in GnRH and subsequent FSH secretion. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $51.00 $292.00 | 3 | |
Progesterone has the capacity to downregulate FSH expression by changing the pulsatility of GnRH release, which is crucial for the rhythmic production of FSH. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole inhibits steroid biosynthesis enzymes, leading to reduced steroid levels that could subsequently decrease FSH expression by altering the hormonal feedback loop. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $140.00 $680.00 | ||
12β-Hydroxydigitoxin may suppress FSH secretion by increasing central dopamine levels, which can inhibit GnRH release and thus lower FSH production. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
As a neurotransmitter, dopamine can decrease FSH secretion by inhibiting GnRH neurons in the hypothalamus, thereby reducing the release of FSH from the pituitary. | ||||||
Triptorelin | 57773-63-4 | sc-396102 | 10 mg | $236.00 | ||
Triptorelin, as a GnRH agonist, initially causes an increase in FSH production, but chronic administration leads to receptor downregulation and a subsequent sustained decrease in FSH expression. | ||||||
Abiraterone | 154229-19-3 | sc-460288 | 10 mg | $276.00 | ||
Abiraterone inhibits the enzyme CYP17, crucial for androgen production, which can lead to a decrease in FSH expression due to lowered androgen-mediated negative feedback. | ||||||
Letrozole | 112809-51-5 | sc-204791 sc-204791A | 25 mg 50 mg | $85.00 $144.00 | 5 | |
Letrozole, by inhibiting the aromatase enzyme, reduces estrogen synthesis, which can lead to an increase in GnRH and a concomitant decrease in FSH production due to disrupted feedback signals. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Spironolactone, through its anti-androgenic activity, may reduce FSH secretion by decreasing the levels of androgens that usually provide negative feedback to the hypothalamic-pituitary axis. | ||||||
ERB 041 | 524684-52-4 | sc-362734 sc-362734A | 10 mg 50 mg | $219.00 $877.00 | ||
ERB 041 acts as an estrogen receptor modulator and can decrease FSH secretion by binding to estrogen receptors in the hypothalamus and pituitary, thereby disrupting the normal estrogen-mediated feedback necessary for FSH production. | ||||||