Date published: 2025-10-15

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FRS2 Inhibitors

FRS2 inhibitors constitute a distinctive class of chemical compounds that primarily target the intracellular protein known as Fibroblast Growth Factor Receptor Substrate 2 (FRS2). FRS2 is a crucial signaling intermediary within intricate cellular pathways responsible for regulating various biological processes. These inhibitors are meticulously crafted to selectively modulate the activity of FRS2, consequently influencing downstream signaling cascades that FRS2 governs. The intricate design of FRS2 inhibitors revolves around their ability to disrupt the interactions between FRS2 and other critical proteins or molecules implicated in the transmission of cellular signals. By precisely binding to FRS2 or modifying its structural conformation, these inhibitors introduce perturbations in the normal course of cellular signaling events. This perturbation, in turn, has the ability to bring about nuanced alterations in cellular responses. Scientists and researchers delve deep into the molecular intricacies of FRS2 inhibitors, aiming to unravel the precise mechanisms through which these compounds exert their effects. Exploration of FRS2 inhibitors represents a dynamic field within the realm of molecular biology and cellular signaling. The intricate interplay between FRS2 and its inhibitors opens avenues for advancing our understanding of fundamental cellular processes. As scientists continue to decipher the underlying mechanisms of FRS2 inhibitors, it offers the prospect of unveiling novel insights into cellular regulation, paving the way for innovative strategies in the broader landscape of biological research.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Erdafitinib

1346242-81-6sc-507388
10 mg
$138.00
(0)

Erdafitinib is an inhibitor of FRS2 and other fibroblast growth factor receptors.

BGJ398

872511-34-7sc-364430
sc-364430A
sc-364430B
sc-364430C
5 mg
10 mg
50 mg
100 mg
$212.00
$247.00
$582.00
$989.00
4
(1)

BGJ398 is an inhibitor of multiple fibroblast growth factor receptors, including FRSIt has been investigated for its potential in various cancers, including gastric, bladder, and lung cancers.

Dovitinib, Free Base

405169-16-6sc-396771
sc-396771A
10 mg
25 mg
$170.00
$350.00
(0)

Dovitinib is a multikinase inhibitor that targets FRS2 along with other receptor tyrosine kinases. It has been evaluated in laboratory settings for its efficacy in various cancers.

AZD4547

1035270-39-3sc-364421
sc-364421A
5 mg
10 mg
$198.00
$309.00
6
(1)

AZD4547 is an experimental FRS2 inhibitor that has been investigated for its potential in various cancers, particularly those with aberrant fibroblast growth factor receptor signaling.

Debio-1347

1265229-25-1sc-507386
10 mg
$324.00
(0)

Debio-1347 is an investigational FRS2 inhibitor that has shown activity against cancers with FRS2 alterations.