FRS2 Activators
FRS2 (Fibroblast Growth Factor Receptor Substrate 2) activators represent a class of chemical compounds that play a crucial role in cell signaling pathways, particularly those associated with growth and differentiation. FRS2 itself is a critical protein found in various tissues of the human body and serves as an adaptor molecule that links extracellular signals, often initiated by growth factors like Fibroblast Growth Factors (FGFs), to intracellular signaling cascades. These signaling cascades are essential for regulating fundamental cellular processes such as proliferation, differentiation, and survival. FRS2 activators are designed to modulate the activity of FRS2, thereby influencing downstream signaling events.
At a molecular level, FRS2 activators can function through various mechanisms. Some compounds may enhance the phosphorylation of FRS2, which is a key step in its activation. This phosphorylation allows FRS2 to bind to other proteins involved in the signaling pathway, ultimately leading to the activation of intracellular kinases like ERK (Extracellular Signal-Regulated Kinase) and AKT (Protein Kinase B). By promoting these signaling events, FRS2 activators can elicit a cascade of cellular responses, including changes in gene expression, cell growth, and differentiation. The precise mode of action and chemical structure of FRS2 activators can vary, offering researchers a versatile toolset to explore and manipulate cell signaling pathways, contributing to a deeper understanding of fundamental biological processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased cAMP levels. Elevated cAMP levels activate PKA, which can phosphorylate and activate transcription factors influencing FRS2. The indirect activation by Forskolin occurs through the cAMP/PKA signaling pathway, modulating the expression and activity of FRS2 through downstream events. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid modulates gene expression by binding to retinoic acid receptors (RARs). RARs can influence FRS2 expression and activity. The indirect activation by Retinoic Acid involves the RAR-mediated transcriptional regulation, leading to altered FRS2 levels and function within cellular contexts. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II activates the AT1 receptor, influencing intracellular signaling pathways. The AT1 receptor can impact FRS2 expression and activity. The indirect activation by Angiotensin II involves the AT1 receptor-mediated signaling, leading to altered FRS2 levels and function within cellular contexts. | ||||||
Icariin | 489-32-7 | sc-279198 sc-279198A sc-279198B sc-279198C | 1 g 5 g 10 g 100 g | $145.00 $421.00 $830.00 $3050.00 | ||
Icariin activates the PI3K/Akt pathway, leading to the phosphorylation and activation of FRS2. The indirect activation by Icariin involves the PI3K/Akt pathway, modulating the activity of FRS2 through phosphorylation-mediated mechanisms. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels. Elevated calcium levels can influence FRS2 through calcium-dependent signaling pathways. The indirect activation by A23187 involves calcium-dependent signaling, leading to altered FRS2 expression and activity within cellular contexts. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin binds to its receptor, initiating intracellular signaling cascades. Insulin receptor activation can impact FRS2 through the PI3K/Akt pathway. The indirect activation by Insulin involves the insulin receptor-mediated signaling, triggering events that modulate FRS2 expression and activity through the PI3K/Akt pathway. | ||||||
(Glp1)-Apelin-13 | 217082-60-5 | sc-359030 | 1 mg | $161.00 | 2 | |
(Glp1)-Apelin-13 binds to its receptor, APJ, initiating intracellular signaling cascades. APJ receptor activation can impact FRS2 through the PI3K/Akt pathway. The indirect activation by Apelin involves APJ receptor-mediated signaling, triggering events that modulate FRS2 expression and activity through the PI3K/Akt pathway. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride activates the Wnt/β-catenin pathway, which can influence FRS2 expression and activity. The indirect activation by Lithium Chloride involves the Wnt/β-catenin pathway, leading to altered FRS2 levels and function within cellular contexts. | ||||||