Filensin Inhibitors
Filensin inhibitors are chemical compounds that specifically target and inhibit the function of filensin, a protein that is a key component of the beaded filament structure in the lens fibers of the eye. Filensin, along with another protein called phakinin, is essential for maintaining the structural integrity and transparency of the lens by forming intermediate filaments. These filaments play a role in the organization and stabilization of the cytoskeletal framework within lens fibers, contributing to the proper arrangement of cells that allows for light transmission. Inhibitors of filensin disrupt its ability to participate in filament formation, leading to alterations in the structural organization of the lens.
By inhibiting filensin, researchers can study the protein's role in the development and maintenance of the lens architecture and its impact on cellular organization. Filensin inhibitors are valuable tools for exploring how the beaded filament system contributes to the mechanical properties and transparency of the lens. Through the application of these inhibitors, scientists can observe changes in cytoskeletal dynamics, cellular adhesion, and the maintenance of lens clarity. These compounds also provide insights into how disruptions in intermediate filament assembly can lead to structural instability within lens fibers, offering a better understanding of the processes that regulate cellular arrangement and transparency in the eye. Filensin inhibitors, therefore, serve as critical tools in the study of cytoskeletal proteins and their role in maintaining cellular and tissue-level integrity, particularly within highly specialized cells such as those in the lens.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may downregulate Filensin by binding to retinoic acid receptors, which can alter the transcriptional activity of genes, potentially leading to a decrease in the transcription of the Filensin gene. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate could reduce Filensin synthesis by inhibiting the enzyme dihydrofolate reductase, leading to a diminished pool of folate coenzymes and thus decreased availability of purine nucleotides necessary for Filensin mRNA synthesis. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D may inhibit Filensin expression by intercalating within DNA sequences, obstructing the elongation phase of RNA polymerase during mRNA transcription for the Filensin gene. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin could decrease Filensin levels by inserting itself between DNA base pairs, thereby disrupting the transcriptional machinery's access to the Filensin gene and limiting its expression. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C may inhibit the expression of Filensin by forming DNA adducts upon cellular activation, which interferes with DNA replication and transcription processes within the Filensin gene locus. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine could downregulate Filensin mRNA by intercalating into DNA and RNA, which might obstruct proper transcription and splicing of the Filensin gene transcript. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
\Fluorouracil may inhibit the expression of Filensin by being incorporated into RNA in place of uracil, which can lead to a disruption of the normal processing and function of Filensin mRNA. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin could reduce Filensin expression by forming covalent bonds with DNA, creating crosslinks that hinder the transcription of the Filensin gene by physically blocking the movement of RNA polymerase along the DNA. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea may lower Filensin levels by inhibiting ribonucleotide reductase, leading to a decreased pool of deoxyribonucleotides required for DNA synthesis during Filensin gene replication and transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate could downregulate Filensin by inhibiting histone deacetylases, leading to a hyperacetylated chromatin state that alters the accessibility of transcription factors to the Filensin gene promoter, reducing its transcriptional activity. | ||||||