FHR-5 Activators
FHR-5 Activators encompass a diverse group of chemical compounds that can enhance the functional activity of FHR-5 through various specific signaling pathways and cellular processes. Phorbol 12-myristate 13-acetate, for instance, activates PKC, which is known to phosphorylate a myriad of proteins. If FHR-5 is among those proteins or is associated with them, PKC activation by PMA can lead to enhanced FHR-5 activity. Similarly, Forskolin's ability to elevate intracellular cAMP levels, leading to PKA activation, could result in downstream effects that phosphorylate and enhance the functional activity of FHR-5. Ionomycin, by increasing intracellular calcium, could activate kinases that target FHR-5, while Isoproterenol could enhance FHR-5 activity through β-adrenergic signaling pathways, again possibly involving cAMP and PKA.
Further, Nitric Oxide Donor SNAP can increase cGMP levels, influencing the activity of cGMP-dependent protein kinases, which may have a subsequent enhancing effect on FHR-5. Lithium chloride's inhibition of GSK-3 might stabilize and accumulate positive regulators of FHR-5, leading to its enhanced activity. Retinoic Acid has thecapability to modulate gene expression, upregulating proteins that enhance FHR-5's function. Estrogen, through its receptors, can influence gene expression that may culminate in the activation of FHR-5. Dibutyryl cAMP, a synthetic analogue of cAMP, activates PKA, which could phosphorylate regulatory proteins associated with FHR-5, resulting in enhanced activity. Curcumin's ability to inhibit NF-κB could lead to the altered expression of proteins that regulate FHR-5, thereby enhancing its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can enhance the phosphorylation of target proteins. In the context of FHR-5, PKC activation can lead to phosphorylation events that directly increase FHR-5 activity if FHR-5 is a substrate for PKC or if PKC phosphorylation alters signaling molecules that interact with FHR-5. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels and activating PKA. Elevated PKA activity can lead to the phosphorylation of proteins that associate with or regulate FHR-5 function, thereby enhancing FHR-5 activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calcium-dependent kinases. These kinases could phosphorylate FHR-5 or its associated proteins, enhancing the functional activity of FHR-5. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol, a β-adrenergic agonist, increases cAMP and activates PKA. PKA can then phosphorylate proteins that modulate FHR-5's activity, leading to its enhanced function. | ||||||
NOC-18 | 146724-94-9 | sc-202247 sc-202247A sc-202247B sc-202247C | 10 mg 50 mg 100 mg 500 mg | $51.00 $184.00 $305.00 $1122.00 | 18 | |
SNAP releases nitric oxide, which activates guanylyl cyclase and increases cGMP. This can lead to the activation of cGMP-dependent protein kinases that may phosphorylate and enhance the activity of FHR-5. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, a negative regulator of the Wnt signaling pathway. Inhibition of GSK-3 can lead to the stabilization and accumulation of proteins that positively regulate FHR-5 activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid modulates gene expression through its receptors. This can lead to the upregulation of proteins or signaling pathways that enhance FHR-5 activity. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estrogen binds to estrogen receptors and influences gene expression. This can result in the upregulation of signaling pathways or molecules that enhance the activity of FHR-5. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl cAMP is a cAMP analogue that activates PKA. PKA can phosphorylate and enhance the activity of proteins associated with the regulation of FHR-5. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB activity, leading to changes in the expression of proteins that regulate the function of FHR-5, thus potentially enhancing its activity. | ||||||