Ferrochelatase Activators
The chemical class known as Ferrochelatase Activators comprises a diverse set of compounds that directly or indirectly enhance the enzymatic activity of ferrochelatase, a crucial enzyme in heme biosynthesis. Hemin, ALA (5-Aminolevulinic acid), sodium ferrous citrate, and hematin, serve as direct activators by acting as substrates or providing essential cofactors, facilitating the final step of heme biosynthesis and supporting cellular processes reliant on heme production. Zinc Protoporphyrin (ZnPP), ferric chloride, nitric oxide, and cobalt chloride act as both direct and indirect activators by influencing metal ion availability or cellular redox status. These compounds enhance ferrochelatase catalytic activity, ensuring proper heme biosynthesis and supporting cellular processes dependent on heme production.
N-Acetylcysteine (NAC), alpha-ketoglutarate, and melatonin act as indirect activators by modulating cellular thiol-disulfide homeostasis, influencing metabolism, or maintaining cellular redox balance. These indirect activations promote heme biosynthesis, supporting cellular processes reliant on heme production through the modulation of various cellular pathways connected to ferrochelatase function. The diversity in mechanisms exhibited by Ferrochelatase Activators highlights the intricate regulation of heme biosynthesis and the essential role these compounds play in supporting cellular processes dependent on proper heme production.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hemin chloride | 16009-13-5 | sc-202646 sc-202646A sc-202646B | 5 g 10 g 25 g | $102.00 $160.00 $326.00 | 9 | |
Hemin, also known as heme, serves as a direct activator of ferrochelatase by acting as a substrate. Hemin is incorporated into the enzyme's active site, promoting the conversion of protoporphyrin IX to heme. This direct activation enhances the catalytic activity of ferrochelatase, facilitating the final step of heme biosynthesis and supporting cellular processes reliant on heme production. | ||||||
Citric Acid Trisodium Salt | 68-04-2 | sc-214745 sc-214745A sc-214745B sc-214745C | 100 g 500 g 1 kg 5 kg | $41.00 $61.00 $82.00 $321.00 | ||
Sodium ferrous citrate serves as a direct activator of ferrochelatase by providing a source of ferrous ions, essential cofactors for the enzyme. The increased availability of ferrous ions enhances the catalytic activity of ferrochelatase, facilitating the insertion of iron into protoporphyrin IX and promoting heme biosynthesis. | ||||||
Hematin | 15489-90-4 | sc-207729 sc-207729A sc-207729D sc-207729C | 250 mg 1 g 100 g 10 g | $73.00 $80.00 $5728.00 $734.00 | 1 | |
Hematin, similar to hemin, is a direct activator of ferrochelatase by acting as a substrate for the enzyme. Hematin is incorporated into the enzyme's active site, promoting the conversion of protoporphyrin IX to heme. This direct activation enhances the catalytic activity of ferrochelatase, facilitating the final step of heme biosynthesis and supporting cellular processes reliant on heme production. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc Protoporphyrin (ZnPP) serves as a direct activator of ferrochelatase by acting as a substrate for the enzyme. ZnPP is incorporated into the enzyme's active site, promoting the conversion of protoporphyrin IX to zinc protoporphyrin, a heme analog. This direct activation enhances the catalytic activity of ferrochelatase, supporting cellular processes reliant on heme production and ensuring proper functioning of ferrochelatase in the heme biosynthetic pathway. | ||||||
Iron(III) chloride | 7705-08-0 | sc-215192 sc-215192A sc-215192B | 10 g 100 g 500 g | $41.00 $46.00 $87.00 | ||
Ferric chloride serves as a direct activator of ferrochelatase by providing ferric ions, essential cofactors for the enzyme. The increased availability of ferric ions enhances the catalytic activity of ferrochelatase, facilitating the insertion of iron into protoporphyrin IX and promoting heme biosynthesis. This direct activation supports cellular processes reliant on heme production and ensures proper functioning of ferrochelatase in the heme biosynthetic pathway. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $64.00 $176.00 | 7 | |
Cobalt chloride serves as an indirect activator of ferrochelatase by influencing metal ion availability. Cobalt chloride increases the concentration of metal ions, supporting the enzyme's catalytic activity by providing essential cofactors. This indirect activation facilitates the insertion of iron into protoporphyrin IX, promoting heme biosynthesis and ensuring proper functioning of ferrochelatase in the heme biosynthetic pathway through alterations in metal ion concentrations. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetyl-L-cysteine (NAC) serves as an indirect activator of ferrochelatase by replenishing cellular glutathione levels. Increased glutathione availability can enhance the enzyme's catalytic activity by maintaining proper redox balance, supporting heme biosynthesis. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
Alpha-ketoglutarate serves as an indirect activator of ferrochelatase by influencing cellular metabolism. As a precursor in the tricarboxylic acid (TCA) cycle, alpha-ketoglutarate supports cellular energy metabolism, indirectly enhancing ferrochelatase activity. This indirect activation promotes heme biosynthesis, supporting cellular processes reliant on heme production through the modulation of metabolic pathways connected to ferrochelatase function. | ||||||
Melatonin | 73-31-4 | sc-207848 sc-207848A sc-207848B sc-207848C sc-207848D sc-207848E | 1 g 5 g 25 g 100 g 250 g 1 kg | $65.00 $73.00 $218.00 $697.00 $1196.00 $3574.00 | 16 | |
Melatonin acts as an indirect activator of ferrochelatase by modulating cellular redox status. Melatonin's antioxidant properties can maintain proper redox balance, indirectly enhancing the enzyme's catalytic activity. This indirect activation promotes heme biosynthesis, supporting cellular processes reliant on heme production through the modulation of cellular redox homeostasis. | ||||||