FER1L5 Inhibitors

FER1L5 inhibitors includes molecules that target the PI3K/Akt pathway (Wortmannin, LY294002), a key pathway for regulating cell growth and survival, which could have implications for the function of FER1L5 if it is involved in similar cellular responses. Inhibitors like PD98059, SP600125, and SB203580 modulate the MAPK family of proteins (ERK, JNK, p38), which are integral to cellular responses to a variety of external stress signals. By influencing these pathways, such inhibitors can alter the activity of proteins that are responsive to or modulated by MAPK signaling.

Inhibitors such as U73122 and Go6983 target enzymes like phospholipase C and protein kinase C, respectively, which are pivotal in the transduction of signals from the cell surface to the inside of the cell, potentially influencing proteins that are part of these signaling cascades. PP2 and NSC23766 selectively inhibit tyrosine kinases and small GTPases like Src and Rac1, respectively, affecting signaling mechanisms that could be crucial for the regulation of FER1L5. Y-27632 and ML7 are inhibitors that affect the actin cytoskeleton by targeting Rho-associated protein kinase and MLCK, respectively, potentially impacting proteins associated with cytoskeletal dynamics. Furthermore, BAPTA-AM, by chelating intracellular calcium, can influence calcium-mediated signaling events, which could affect proteins that are regulated by calcium levels within the cell.