Fatso Activators
Fatso Activators encompass a range of compounds that interact with cellular metabolic pathways, indirectly influencing the activity of the α-ketoglutarate-dependent dioxygenase FTO. These chemicals do not activate FTO directly but modulate various biochemical pathways that can impact FTO's functionality. The primary mode of interaction is through influencing the metabolic state of the cell, as FTO plays a critical role in energy homeostasis and nucleic acid demethylation processes.
The compounds in this class are primarily intermediates or cofactors in metabolic pathways, such as the Krebs cycle, glycolysis, and redox reactions. For instance, α-Ketoglutarate and Succinic acid, as Krebs cycle intermediates, directly impact cellular energy metabolism, potentially modulating FTO's activity in response to changes in the energy state of the cell. Similarly, cofactors like NAD+ and ATP, integral to various metabolic reactions, can alter the metabolic landscape, indirectly influencing FTO activity. Ascorbic acid and Iron (II) sulfate are particularly notable as they maintain the functionality of iron-dependent dioxygenases like FTO. Ascorbic acid helps in maintaining iron in its reduced state, essential for FTO's catalytic activity, while Iron (II) sulfate acts as a direct cofactor.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Ornithine-α-ketoglutarate | 5191-97-9 | sc-475792 | 100 g | $32.00 | ||
α-Ketoglutarate is a key intermediate in the Krebs cycle. It can facilitate the activity of α-ketoglutarate-dependent dioxygenases, including FTO, by serving as a co-substrate. | ||||||
Ferrous Sulfate (Iron II Sulfate) Heptahydrate | 7782-63-0 | sc-211505 sc-211505A | 250 g 500 g | $72.00 $107.00 | ||
As an essential cofactor for FTO, Iron (II) sulfate is crucial for its catalytic activity. FTO requires iron for its demethylation process. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Ascorbic acid can enhance the activity of iron-dependent dioxygenases by maintaining iron in its reduced (Fe2+) state, which is necessary for FTO function. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $44.00 $74.00 $130.00 | ||
Succinic acid, a component of the Krebs cycle, can influence cellular metabolism, potentially affecting the energy balance and indirectly modulating FTO activity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+, a coenzyme in redox reactions, can influence the cellular metabolic state, indirectly affecting FTO activity through metabolic regulation. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $38.00 $74.00 | 9 | |
ATP, as the primary energy currency of the cell, can influence various metabolic pathways, potentially impacting FTO's role in energy balance and metabolism. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $76.00 $2050.00 | 8 | |
Glutathione in its reduced form can maintain cellular redox state, which might indirectly influence FTO activity through redox-sensitive signaling pathways. | ||||||
Pyruvic acid | 127-17-3 | sc-208191 sc-208191A | 25 g 100 g | $40.00 $94.00 | ||
As an end product of glycolysis, pyruvate’s levels can reflect cellular energy status, potentially influencing FTO activity in response to metabolic changes. | ||||||
Oxaloacetic Acid | 328-42-7 | sc-279934 sc-279934A sc-279934B | 25 g 100 g 1 kg | $300.00 $944.00 $7824.00 | 1 | |
Involved in the Krebs cycle, oxaloacetate may impact cellular energy metabolism, thereby indirectly affecting FTO activity. | ||||||
Citric Acid, Anhydrous | 77-92-9 | sc-211113 sc-211113A sc-211113B sc-211113C sc-211113D | 500 g 1 kg 5 kg 10 kg 25 kg | $49.00 $108.00 $142.00 $243.00 $586.00 | 1 | |
A key Krebs cycle intermediate, citric acid can influence cellular metabolism, potentially modulating FTO activity indirectly. | ||||||