FASTKD2 Activators
Chemical activators of Fas-activated serine/threonine kinase domain 2 (FASTKD2) can engage multiple cellular pathways to modulate its activity. The compound AICAR, for instance, can activate AMP-activated protein kinase (AMPK), a key regulator of energy balance within the cell. The activation of AMPK by AICAR can lead to enhanced mitochondrial activity, which is a context where FASTKD2 operates. Similarly, metformin, berberine, and quercetin, all known to activate AMPK, can also support mitochondrial function and thereby increase the activity of FASTKD2. The activation of AMPK signals a boost in mitochondrial biogenesis and function, creating an environment that fosters the activity of mitochondrial proteins, including FASTKD2.
On another front, compounds like SRT1720 and resveratrol activate SIRT1, a member of the sirtuin family of proteins that is known to influence the aging process by affecting cellular metabolism and mitochondrial biogenesis. The activation of SIRT1 by these compounds leads to the deacetylation and activation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), further promoting the biogenesis of mitochondria. This, in turn, can enhance the function of mitochondrial proteins such as FASTKD2. Moreover, PPAR agonists like pioglitazone and bezafibrate activate peroxisome proliferator-activated receptors, which are nuclear receptors that play a pivotal role in the regulation of mitochondrial genes and can support the function of FASTKD2. Leucine, an amino acid known to activate the mTOR pathway, can increase protein synthesis and mitochondrial biogenesis, which may also support the activity of FASTKD2. Lastly, nicotinamide riboside, as a precursor of NAD+, can boost the levels of this crucial cofactor, thereby activating SIRT1 and supporting the function of FASTKD2.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK), which is known to regulate cellular energy homeostasis. Since FASTKD2 is involved in mitochondrial biogenesis and function, activation of AMPK by AICAR could enhance mitochondrial activity and thus increase the functional activity of FASTKD2. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $193.00 $357.00 | 13 | |
SRT1720 is an activator of SIRT1, which is implicated in mitochondrial biogenesis through the deacetylation of PGC-1α, a master regulator of mitochondrial gene expression. Activation of SIRT1 by SRT1720 can promote the deacetylation and activation of PGC-1α, leading to increased mitochondria biogenesis and potentially enhancing the activity of mitochondrial proteins such as FASTKD2. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to activate SIRT1, which plays a role in mitochondrial function and biogenesis. By activating SIRT1, resveratrol may promote mitochondrial biogenesis and the activation of mitochondrial proteins, including FASTKD2. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone is a PPAR-γ agonist that enhances the expression of genes involved in mitochondrial function and biogenesis. The activation of PPAR-γ can lead to improved mitochondrial function and potentially increased activity of mitochondrial proteins such as FASTKD2. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Bezafibrate activates PPARs, including PPAR-α, which is involved in the regulation of genes encoding mitochondrial proteins. Through the activation of PPAR-α, bezafibrate can promote mitochondrial function and potentially enhance the functional activity of FASTKD2 within the mitochondria. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin is known to activate AMPK, thereby promoting mitochondrial biogenesis and function. Through the activation of AMPK, metformin can have an indirect effect on the activity of mitochondrial proteins, including FASTKD2. | ||||||
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $61.00 | ||
Leucine can activate the mTOR pathway, which is involved in protein synthesis and mitochondrial biogenesis. Activation of mTOR by leucine could result in increased mitochondrial protein synthesis and improved function, potentially enhancing the activity of FASTKD2. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine has been shown to activate AMPK. By activating AMPK, berberine can improve mitochondrial function and potentially enhance the functional activity of FASTKD2. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is known to activate AMPK. Similar to other AMPK activators, quercetin can promote mitochondrial biogenesis and function, which may lead to an increase in the activity of FASTKD2. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
α-Lipoic acid is an antioxidant that can influence mitochondrial biogenesis and is known to activate AMPK. Through its action on AMPK, α-Lipoic acid could enhance mitochondrial function and indirectly increase the activity of FASTKD2. | ||||||