Fascin 2 Activators
Fascin 2 activators are a specific set of chemical compounds that enhance the functional activity of Fascin 2 by modulating the actin cytoskeleton and its associated dynamics, which are central to Fascin 2's role in the cell. Jasplakinolide and Phalloidin directly stabilize actin filaments, thus providing a scaffold for Fascin 2 to bind and bundle, enhancing its activity. Methyl Jasmonate impacts the cytoskeletal architecture, potentially creating conditions favorable for Fascin 2-mediated actin bundling. Forskolin, through cAMP elevation, may induce changes in actin organization, indirectly facilitating Fascin 2 function. Phosphatidylinositol 4,5-bisphosphate (PIP2) specifically modulates the actin cytoskeleton and can potentiate Fascin 2's actin-bundling activity by altering the actin-binding sites.
The second set of activators includes Calyculin A and Okadaic Acid, which inhibit protein phosphatases and lead to hyperphosphorylation, affecting the cytoskeletal structure and potentially increasing Fascin 2 activity. Cytochalasin D and Latrunculin A disrupt actin polymerization; however, their removal can lead to rapid actin reassembly, providing a burst of filamentous actin that Fascin 2 can bundle. Swinholide A, Jaspisamide A, and Misakinolide A interact with actin in various ways, such as severing filaments or promoting polymerization, which could lead to increased Fascin 2 activity due to the enhanced availability of actin filaments for bundling. Through these multifaceted interactions with the actin cytoskeleton, these compounds collectively contribute to the enhancement of Fascin 2's role in organizing actin into functional structures within cells.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide stabilizes actin filaments and can enhance the bundling activity of Fascin 2 by increasing the local concentration of F-actin, thus providing more substrate for Fascin 2 to act upon. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Phalloidin binds and stabilizes F-actin, thereby potentially enhancing the activity of Fascin 2 by augmenting the availability of bundled actin filaments. | ||||||
(±)-Methyl Jasmonate | 39924-52-2 | sc-205386 sc-205386A sc-205386B sc-205386C sc-205386D sc-205386E sc-205386F | 1 g 5 g 10 g 50 g 100 g 500 g 1 kg | $36.00 $105.00 $204.00 $890.00 $1671.00 $7081.00 $12491.00 | ||
Methyl Jasmonate influences cytoskeletal rearrangement, which may lead to the activation of Fascin 2 as part of the reorganization process in the cell. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which can lead to changes in actin dynamics, potentially enhancing the activity of actin-bundling proteins like Fascin 2. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases PP1 and PP2A, leading to increased phosphorylation within the cell, which may indirectly enhance the bundling activity of Fascin 2 by affecting actin dynamics. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to hyperphosphorylation and subsequent changes in cytoskeletal organization that may enhance Fascin 2 activity. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A disrupts actin polymerization, and upon withdrawal, it can lead to a rapid and robust actin filament assembly, which Fascin 2 could potentially organize into bundles. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D binds to the barbed ends of actin filaments, preventing further polymerization and potentially enhancing Fascin 2 activity during filament reassembly. | ||||||