FAM21A-D Activators
FAM21A-D Activators encompass a series of compounds that indirectly heighten the protein's functional activity via distinct signaling pathways. Forskolin, by increasing cAMP levels, indirectly augments FAM21A-D's activity through the cAMP-dependent PKA pathway, likely affecting phosphorylation of proteins that associate with or regulate FAM21A-D. PMA and 8-Bromo-cAMP also support this protein's activity, with PMA acting through PKC activation, which could phosphorylate key proteins in FAM21A-D-related vesicular trafficking pathways. Ionomycin and A23187, by elevating intracellular calcium levels, might enhance FAM21A-D by engaging calcium-dependent signaling, crucial for the pathways that FAM21A-D is part of.
The suite of FAM21A-D activators orchestrates a symphony of intracellular signals that converge to enhance the activity of FAM21A-D through multiple, distinct biochemical pathways. Forskolin, with its ability to elevate intracellular cAMP levels, indirectly potentiates the activity of FAM21A-D by stimulating the cAMP/PKA signaling axis, which is known to phosphorylate substrates that could interact with or regulate FAM21A-D, suggesting a post-translational enhancement of FAM21A-D function. Similarly, the cAMP analog 8-Bromo-cAMP serves to amplify this route, ensuring a robust PKA-mediated response that could affect FAM21A-D-related processes. Ionomycin and A23187, both agents that increase intracellular calcium, may activate calcium-dependent kinases or phosphatases, thus influencing the phosphorylation state of proteins within FAM21A-D's sphere of influence, particularly those implicated in cytoskeletal organization and vesicular transport.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as a selective calcium ionophore, increasing intracellular calcium concentrations and potentially enhancing FAM21A-D activity through calcium-dependent signaling pathways that FAM21A-D is involved in. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates Protein Kinase C (PKC), which could lead to enhanced FAM21A-D activity by phosphorylation of proteins in pathways where FAM21A-D is involved, specifically in vesicular trafficking. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA and could enhance FAM21A-D activity by modulating the same cAMP-dependent pathways as Forskolin. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, potentially enhancing the phosphorylation status of proteins within FAM21A-D pathways, thereby indirectly increasing FAM21A-D activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A, similar to Okadaic acid, inhibits protein phosphatases, leading to increased phosphorylation within the signaling pathways that could enhance FAM21A-D activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor that may enhance FAM21A-D activity by reducing inhibitory phosphorylation events in pathways where FAM21A-D is active. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that could enhance FAM21A-D activity by altering downstream signaling pathways, such as AKT, thus potentially modulating FAM21A-D's role in vesicular trafficking. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which could enhance FAM21A-D activity by modulating autophagy pathways that intersect with FAM21A-D's function in vesicle formation and trafficking. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that could enhance FAM21A-D activity through the MAPK/ERK pathway, which may influence the phosphorylation state of proteins interacting with FAM21A-D. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that may enhance FAM21A-D activity by shifting signaling dynamics in pathways where FAM21A-D operates, specifically stress response pathways linked to vesicular trafficking. | ||||||