FAM164A Activators
FAM164A Activators represent a collection of compounds that influence cellular signaling pathways or processes, leading to the activation of FAM164A. Forskolin raises intracellular cAMP levels, which activates PKA, resulting in phosphorylation and enhancement of FAM164A's role in cellular signaling. Similarly, okadaic acid and calyculin A inhibit phosphatases PP1 and PP2A, maintaining FAM164A in a phosphorylated state, while PMA activates PKC, leading to the phosphorylation of a range of substrates including FAM164A.
Ionomycin raises intracellular calcium levels, activating calcium-dependent kinases that phosphorylate FAM164A, integrating it into calcium signaling pathways. KN-93 inhibits CaMKII, which may trigger compensatory activation of FAM164A through other calcium-dependent mechanisms. Thapsigargin disrupts calcium homeostasis, leading to the activation of calcium-dependent kinases that enhance the function of FAM164A. Anisomycin activates stress-activated protein kinases, which leads to the enhancement of FAM164A's function in stress response. Lithium chloride inhibits GSK-3, leading to increased phosphorylation and activity of FAM164A. H-89, by inhibiting PKA, could sensitize other kinases that indirectly activate FAM164A. MG-132 prevents the degradation of phosphorylated proteins, possibly enhancing FAM164A's activity by stabilizing its active form. Lastly, cyclosporin A inhibits calcineurin, thereby potentially enhancing FAM164A activity through alternative calcium-mediated signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels within the cell. This inhibition results in the enhanced phosphorylation and activation of FAM164A. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calcium-dependent kinases that phosphorylate FAM164A, thus enhancing its activity in calcium signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which then phosphorylates a broad range of substrates including FAM164A, leading to its functional enhancement within various signaling pathways. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases PP1 and PP2A, similar to okadaic acid, maintaining FAM164A in a phosphorylated and active state by preventing its dephosphorylation. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is an inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). Inhibition of CaMKII can lead to compensatory mechanisms in other calcium-dependent pathways that could enhance the function of FAM164A in response to altered calcium signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin disrupts calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to elevated cytosolic calcium and activation of calcium-dependent kinases that enhance FAM164A function. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases (SAPKs), leading to the phosphorylation and enhancement of proteins involved in the stress response, including FAM164A. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 (GSK-3), a kinase involved in phosphorylation events. Inhibition of GSK-3 leads to an increase in phosphorylation levels of substrates such as FAM164A, enhancing its activity. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is an inhibitor of PKA, and its use can lead to feedback mechanisms that sensitize other kinases or compensatory pathways that could indirectly enhance the phosphorylation and activation of FAM164A. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that can lead to the accumulation of phosphorylated proteins by preventing their degradation. This could indirectly result in the enhanced activity of FAM164A by stabilizing its phosphorylated form. | ||||||