FAM139A Inhibitors
TRPM8 Channel Associated Factor 2 (TCAF2) is a protein that plays a crucial role in modulating the activity of the Transient Receptor Potential Melastatin 8 (TRPM8) ion channel. TRPM8 is a member of the TRP family of ion channels primarily expressed in sensory neurons, where it functions as a thermosensitive receptor for detecting cold temperatures and various chemical compounds. TCAF2 is encoded by the TCAF2 gene and acts as an important regulatory protein associated with TRPM8 function.TCAF2 interacts with TRPM8 channels, influencing their trafficking, localization, and activity within the cell membrane. This interaction is crucial for the proper functioning of TRPM8 channels in sensory neurons and other tissues expressing these channels. By modulating TRPM8 activity, TCAF2 contributes to the cellular responses to cold temperatures and the perception of cold sensations.
Furthermore, TCAF2 may participate in the regulation of signaling pathways downstream of TRPM8 activation. Activation of TRPM8 channels by cold temperatures or chemical agonists leads to intracellular calcium influx and subsequent activation of downstream signaling cascades. TCAF2 could potentially modulate these signaling events by regulating the activity or availability of TRPM8 channels, thereby influencing cellular responses to cold stimuli.Research suggests that dysregulation of TCAF2 expression or function may contribute to altered cold sensitivity and sensory processing. Changes in TCAF2 levels or activity could disrupt normal TRPM8 channel function, leading to aberrant cold perception or sensory abnormalities.Additionally, TCAF2 may have implications beyond cold sensation, as TRPM8 channels are implicated in various physiological and pathological processes, including pain sensation, inflammation, and cancer progression. Further investigation into the molecular mechanisms underlying the interaction between TCAF2 and TRPM8 channels will provide insights into their roles in sensory physiology.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D inhibits RNA polymerase activity, leading to suppression of transcription. Inhibition of transcription could potentially reduce the expression of TRPM8 channel associated factor 2 (TCAF2). | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits protein synthesis by interfering with ribosome function. By preventing new protein synthesis, it may lead to decreased expression of TRPM8 channel associated factor 2 (TCAF2). | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $40.00 $210.00 $816.00 $65.00 | 394 | |
Puromycin causes premature chain termination during protein synthesis, inhibiting protein synthesis. This inhibition of protein synthesis could potentially decrease the expression of TRPM8 channel associated factor 2 (TCAF2). | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin inhibits topoisomerase II, resulting in DNA damage and inhibition of transcription. This could lead to decreased expression of TRPM8 channel associated factor 2 (TCAF2) and other genes. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C is an alkylating agent that crosslinks DNA, inhibiting DNA replication and transcription. This inhibition of gene expression could affect the expression of TRPM8 channel associated factor 2 (TCAF2). | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-Fluorouracil is a pyrimidine analog that interferes with DNA and RNA synthesis. Inhibition of nucleic acid synthesis may lead to decreased expression of TRPM8 channel associated factor 2 (TCAF2) and other genes. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
Bleomycin induces DNA strand breaks, leading to DNA damage and activation of DNA repair mechanisms. This could result in alterations in gene expression, potentially affecting TRPM8 channel associated factor 2 (TCAF2) expression. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
Mitoxantrone inhibits topoisomerase II, causing DNA damage and interference with DNA replication and transcription. This inhibition could potentially lead to decreased expression of TRPM8 channel associated factor 2 (TCAF2). | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin inhibits topoisomerase I, resulting in DNA damage and interference with DNA replication and transcription. This inhibition could potentially lead to decreased expression of TRPM8 channel associated factor 2 (TCAF2). | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin is a platinum-based chemotherapeutic agent that induces DNA damage and activation of DNA repair mechanisms. This could result in alterations in gene expression, potentially affecting TRPM8 channel associated factor 2 (TCAF2) expression. | ||||||