FAM128B Inhibitors

FAM128B Inhibitors belong to a distinct chemical class designed to target and modulate the activity of the FAM128B protein. FAM128B, also known as CCDC88B or DAPLE (Dishevelled-associating protein with a high frequency of leucine residues), is a protein encoded by the FAM128B gene in humans. It is primarily associated with cellular signaling pathways, particularly those involving the Wnt signaling cascade. Wnt signaling plays a crucial role in various biological processes, including embryonic development, tissue homeostasis, and cell proliferation. The FAM128B protein acts as a key mediator within this pathway, facilitating interactions with Dishevelled (Dvl) proteins and contributing to the transduction of Wnt signals across the cell membrane.

FAM128B Inhibitors stems from a desire to selectively modulate the activity of FAM128B, offering a tool to probe the intricacies of Wnt signaling and its downstream effects. These inhibitors typically function by binding to specific sites on the FAM128B protein, disrupting its interactions with other signaling components and consequently altering the cellular responses mediated by Wnt signaling. Researchers are keenly exploring the structural and mechanistic aspects of FAM128B Inhibitors to enhance their specificity and efficacy, providing valuable insights into the regulation of Wnt signaling in diverse cellular contexts