EPX Inhibitors

The class of chemicals identified as EPX inhibitors comprises a diverse range of compounds that can indirectly influence the activity of eosinophil peroxidase. These inhibitors do not directly bind to or deactivate EPX. Instead, they operate by modulating various biochemical pathways and cellular processes that indirectly impact the enzyme's function. For instance, some of these chemicals, such as Ascorbic Acid and Quercetin, function as antioxidants. They mitigate the oxidative products generated by EPX, thereby reducing its effective action within the cellular environment.

Other compounds in this class, such as Diphenyleneiodonium Chloride and Apocynin, target different enzymes or cellular components that are upstream or parallel to the pathways involving EPX. By inhibiting these enzymes, like NADPH oxidase, they consequently alter the cellular redox state, indirectly affecting EPX activity. Additionally, compounds like Indomethacin and Ketoprofen, which influence inflammatory pathways, also play a role in modulating EPX activity.