epsin Inhibitors
Chemical inhibitors of epsin can affect its function in endocytosis by targeting various molecules and processes that are essential for the proper functioning of epsin. Dynasore, MiTMAB, Dyngo-4a, and Ocaperidone all target dynamin, a GTPase crucial for the scission of newly formed vesicles from the plasma membrane. Inhibition of dynamin by these chemicals can significantly disrupt the role of epsin in vesicle formation and release, as epsin is known to interact with the GTPase during the endocytic process. These dynamin inhibitors thereby prevent the successful recruitment of epsin to the sites of vesicle formation and impede its ability to facilitate the endocytosis of cellular cargo.
Other inhibitors such as Pitstop 2, Chlorpromazine, and Tyrphostin A23 disrupt clathrin-mediated endocytosis, which is a pathway where epsin acts as an adaptor protein, linking the clathrin coat to the cell membrane and to other endocytic machinery. By blocking clathrin, these inhibitors indirectly prevent epsin from performing its role in the assembly of clathrin-coated vesicles. Furthermore, Phenylarsine Oxide and Endosidin 2, which impair vesicle trafficking and endocytic trafficking respectively, can alter the normal function of epsin within the cell by modifying the environment in which epsin operates. Additionally, compounds like Monodansylcadaverine and Jasplakinolide can indirectly inhibit epsin by affecting the cytoskeletal dynamics and membrane curvature, both of which are crucial for the endocytic process where epsin is actively engaged. Jasplakinolide's stabilization of actin filaments can particularly disrupt the fine balance of actin polymerization and depolymerization required for endocytic vesicle formation and scission, processes in which epsin is intimately involved.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore is a small molecule that inhibits dynamin, a GTPase involved in vesicular trafficking. Epsin is known to interact with dynamin for endocytosis. Dynasore's inhibition of dynamin can lead to a reduction in endocytosis efficiency, thus indirectly inhibiting epsin's function in endocytic pathways. | ||||||
Pitstop 2 | 1419093-54-1 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 is an inhibitor of clathrin-mediated endocytosis. Epsin functions as an adaptor in clathrin-mediated endocytosis, and inhibition of this process by Pitstop 2 can indirectly inhibit the functional role of epsin in this pathway. | ||||||
Hydroxy-Dynasore | 1256493-34-1 | sc-364678 | 10 mg | $250.00 | ||
Dyngo-4a is a potent inhibitor of dynamin, thus impacting endocytosis. As epsin is involved in the endocytic process, its function can be indirectly inhibited by Dyngo-4a through the disruption of dynamin's activity. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine is known to block clathrin-mediated endocytosis. Since epsin is a clathrin-associated protein, its function in aiding vesicle formation and endocytosis can be indirectly inhibited by Chlorpromazine. | ||||||
Tyrphostin A23 | 118409-57-7 | sc-3554 | 10 mg | $110.00 | 13 | |
Tyrphostin A23 is an inhibitor of receptor-mediated endocytosis. Epsin is involved in this process, and inhibition by Tyrphostin A23 can prevent epsin from effectively participating in the internalization of cargo molecules, thereby indirectly inhibiting its function. | ||||||
Dansylcadaverine | 10121-91-2 | sc-214851 sc-214851A sc-214851B | 100 mg 250 mg 1 g | $51.00 $87.00 $235.00 | 4 | |
Monodansylcadaverine is an inhibitor of transglutaminase and also affects endocytosis. This compound could indirectly inhibit epsin by altering the internalization processes in which epsin is involved. | ||||||
Phenylarsine oxide | 637-03-6 | sc-3521 | 250 mg | $40.00 | 4 | |
Phenylarsine Oxide is an inhibitor of vesicle trafficking and endocytosis. As epsin is essential for endocytic vesicle formation, its functional role can be indirectly inhibited by Phenylarsine Oxide through its action on vesicle trafficking. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide stabilizes actin filaments and can disrupt actin dynamics. Since epsin is involved in endocytosis, which requires actin remodeling, the stabilization of actin filaments by Jasplakinolide can indirectly inhibit epsin's role in vesicle formation and scission. | ||||||