ENT2 Activators
ENT2 activators are a class of chemicals that can enhance the functional activity of ENT2, a nucleoside transporter that plays a critical role in the regulation of purine and pyrimidine nucleoside transport across the cell membrane. These activators exert their effects by either directly binding to ENT2 as substrates or indirectly shifting the equilibrium of transport towards ENT2 by inhibiting its counterpart, ENT1. Substrates of ENT2, such as adenosine, inosine, guanosine, uridine, cytidine, thymidine, deoxyadenosine, and deoxyguanosine, enhance the functional activity of ENT2 by directly binding to the transporter, thereby facilitating the bidirectional transport of nucleosides across the cell membrane. The binding of these substrates to ENT2 stimulates the transporter's exchange activity, leading to an increase in the import and export of nucleosides.
On the other hand, chemicals such as dilazep, dipyridamole, NBMPR, and NBTI, which are known inhibitors of ENT1, can indirectly enhance the functional activity of ENT2. These chemicals inhibit the activity of ENT1, which is thought to shift the equilibrium towards ENT2, thereby enhancing the functional activity of ENT2. This shift in equilibrium provides an additional mechanism for the regulation of nucleoside transport, allowing for the fine-tuning of nucleoside concentrations in various physiological and pathological conditions. This comprehensive list of chemicals indicates a diverse range of mechanisms through which the functional activity of ENT2 can be enhanced.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine is a known substrate of ENT2 and its binding to the transporter can stimulate its activity. ENT2 is a bidirectional transporter, and the binding of adenosine can enhance the exchange of intracellular and extracellular nucleosides. | ||||||
Inosine | 58-63-9 | sc-295182 sc-295182A | 1 g 5 g | $60.00 $92.00 | ||
Inosine, like adenosine, is a substrate of ENT2. The binding of inosine to ENT2 enhances its exchange activity, facilitating the bidirectional transport of nucleosides. | ||||||
Guanosine | 118-00-3 | sc-218575 sc-218575A sc-218575B sc-218575C sc-218575D | 5 g 25 g 250 g 1 kg 5 kg | $40.00 $50.00 $84.00 $250.00 $1103.00 | ||
Guanosine is a purine nucleoside that can bind to and be transported by ENT2. The binding of guanosine enhances the transporter's activity, promoting the exchange of nucleosides across the cell membrane. | ||||||
Uridine | 58-96-8 | sc-296685 sc-296685A | 1 g 25 g | $61.00 $100.00 | 1 | |
Uridine is a substrate for ENT2. Upon binding to ENT2, it enhances the transporter's exchange activity, facilitating the bidirectional transport of nucleosides. | ||||||
Thymidine | 50-89-5 | sc-296542 sc-296542A sc-296542C sc-296542D sc-296542E sc-296542B | 1 g 5 g 100 g 250 g 1 kg 25 g | $49.00 $73.00 $270.00 $458.00 $1758.00 $114.00 | 16 | |
Thymidine is a substrate for ENT2. Its binding to ENT2 can stimulate the transporter's exchange activity, enhancing the bidirectional transport of nucleosides. | ||||||
Dipyridamole | 58-32-2 | sc-200717 sc-200717A | 1 g 5 g | $31.00 $102.00 | 1 | |
Dipyridamole selectively inhibits ENT1, which can increase the functional activity of ENT2. It is thought to shift the equilibrium towards ENT2, thereby enhancing its transporter activity. | ||||||
S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR) | 38048-32-7 | sc-200117 | 50 mg | $163.00 | 1 | |
NBTI is a potent inhibitor of ENT1. By inhibiting ENT1, NBTI can indirectly increase the functional activity of ENT2, enhancing its transporter activity. | ||||||