EMP-3 Activators

EMP-3, short for Epithelial Membrane Protein 3, is a well-characterized transmembrane protein that is part of the tetraspanin family. It is primarily known for its role in cell adhesion, migration, and signal transduction. The tetraspanin family consists of membrane proteins characterized by four transmembrane domains and two extracellular loops. These proteins are widely distributed in various cell types and play diverse roles in cellular processes, including cell adhesion, fusion, and intracellular signaling.

EMP-3, like other tetraspanins, is involved in organizing membrane microdomains known as tetraspanin-enriched microdomains (TEMs) or tetraspanin webs. Within these microdomains, EMP-3 interacts with other proteins, including integrins, growth factor receptors, and other tetraspanins, thereby influencing various cellular functions. EMP-3's role in modulating cell adhesion and migration makes it important in processes such as wound healing, immune response, and cancer metastasis. Its ability to engage in lateral interactions with neighboring proteins within the plasma membrane contributes to the regulation of signal transduction pathways, further underscoring its significance in cellular physiology. While EMP-3's precise functions continue to be explored, its involvement in fundamental cellular processes highlights its importance as a key player in cell biology.