ELAC1 Inhibitors
Chemical inhibitors of ELAC1 can operate through various mechanisms to hinder its function in the cell. Trichostatin A, for instance, can disrupt the acetylation status of histones linked to the ELAC1 protein, affecting the transcription machinery's access to the ELAC1 gene and thus its expression. Chloroquine, accumulating in lysosomes, can impede autophagic pathways that, when inhibited, may lead to cellular stress and consequentially a reduction in the cellular processes including those associated with ELAC1. Rapamycin, known for its inhibition of the mTOR pathway, can lead to a downregulation of ELAC1 by interfering with cellular growth signals that typically upregulate ELAC1 activity. The introduction of 5-Fluorouracil can cause DNA damage, which in turn can lead to a decrease in ELAC1 function as the cell reallocates resources to DNA repair rather than tRNA splicing, where ELAC1 is active. Camptothecin's inhibition of Topoisomerase I can result in excessive DNA supercoiling, which can hinder the transcription of the ELAC1 protein, while Bortezomib's proteasome inhibition can cause an accumulation of misfolded proteins, inducing stress that diverts resources away from RNA processing functions of ELAC1.
Furthermore, Paclitaxel's stabilization of microtubules can indirectly affect ELAC1 by disrupting cellular division and signal transduction processes that are vital for proper RNA processing regulation. Aminoglycosides such as Gentamicin can cause mistranslation in eukaryotic cells, leading to the production of defective ELAC1 proteins due to the incorporation of incorrect amino acids. Cycloheximide's interference with ribosomal translocation can prevent the synthesis of the ELAC1 protein, thus limiting its availability. Actinomycin D, by intercalating into DNA, can block the transcription of the ELAC1 mRNA, which decreases its expression. Mitomycin C's DNA crosslinking can have a similar effect by inhibiting the proper replication and transcription necessary for ELAC1 expression. Lastly, Omacetaxine mepesuccinate inhibits protein synthesis at the initial elongation stage, which can lead to reduced levels of ELAC1 protein in the cell, thereby hindering its function. Each of these chemicals, through their distinct modes of action, can contribute to the inhibition of ELAC1 protein activity within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylase, which can lead to alterations in chromatin structure and gene expression. This could inhibit ELAC1 by altering the acetylation status of histones associated with its gene, affecting the transcription machinery's access to the ELAC1 gene. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine accumulates in lysosomes, which can affect autophagic degradation pathways. By inhibiting autophagy, Chloroquine can increase cellular stress, potentially leading to the inhibition of ELAC1 as the cell prioritizes survival pathways over RNA processing, in which ELAC1 is involved. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is a specific inhibitor of mTOR, a kinase involved in cell growth and proliferation. By inhibiting mTOR, Rapamycin can indirectly inhibit ELAC1 by downregulating cellular processes that are upregulated when ELAC1 is active. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-Fluorouracil is a pyrimidine analog that inhibits thymidylate synthase, leading to DNA damage and affecting DNA repair pathways. As ELAC1 is involved in tRNA splicing, its activity might be indirectly inhibited due to the cell's focus on repairing DNA damage over processing RNA. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin inhibits Topoisomerase I, which is essential for DNA replication and transcription. By inhibiting this enzyme, Camptothecin can indirectly inhibit ELAC1 by causing a buildup of DNA supercoiling and affecting the transcription of RNA processing genes. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib inhibits the proteasome, leading to an accumulation of misfolded proteins and cellular stress. This stress can indirectly inhibit ELAC1 function by diverting cellular resources to protein quality control systems instead of RNA processing. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules, which can disrupt cell division and signal transduction pathways. By altering cell signaling, Paclitaxel can indirectly inhibit ELAC1 by affecting pathways that regulate RNA processing and enzyme activity. | ||||||
Gentamicin Sulfate, 500X Solution | 1405-41-0 | sc-29066A sc-29066 | 10 ml 20 ml | $47.00 $83.00 | 12 | |
Gentamicin binds to the bacterial ribosome and inhibits protein synthesis. In eukaryotic cells, it can cause mistranslation and incorporation of incorrect amino acids. This could lead to the production of nonfunctional ELAC1 protein due to misincorporation of amino acids during its synthesis. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis by interfering with the translocation step on the ribosome. This can indirectly inhibit ELAC1 by preventing its synthesis, thus reducing its functional protein levels in the cell. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates into DNA and prevents the transcriptional elongation by RNA polymerase. This can indirectly inhibit ELAC1 by blocking the transcription of the ELAC1 mRNA, reducing its overall expression and availability. | ||||||