eIF3θ Activators
eIF3θ activators represent a diverse array of chemicals that intricately modulate the activity of eIF3θ, a key component of the eIF3 complex involved in translation initiation. One notable indirect activator is Rapamycin, which inhibits mTOR, a central regulator of protein synthesis. By disrupting the mTOR pathway, Rapamycin indirectly activates eIF3θ, influencing translation initiation processes. AICAR stimulates eIF3θ indirectly by activating AMPK, a cellular energy sensor. This activation influences the AMPK/mTOR signaling axis, leading to eIF3θ activation and impacting translation initiation processes. Salubrinal, another indirect activator, prevents ER stress-induced dephosphorylation of eIF2α, indirectly activating eIF3θ through the unfolded protein response (UPR) pathway.
Direct eIF3θ activation is observed with chemicals like N6-Benzyladenosine, which promotes phosphorylation of eIF3θ. This direct activation modulates translation initiation processes, highlighting the specificity of chemical control over eIF3θ activity. Compounds such as 4EGI-1 disrupt the interaction between eIF4E and 4E-BP1, indirectly activating eIF3θ by influencing the eIF4E-mediated translation initiation pathway. ISRIB, a unique activator, targets the integrated stress response (ISR), indirectly activating eIF3θ by modulating the phosphorylation status of eIF2α. Collectively, these activators offer a comprehensive toolkit for researchers to selectively modulate eIF3θ activity, providing valuable insights into the intricate regulation of translation initiation processes within the cellular context.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin activates eIF3θ indirectly by inhibiting mTOR, a key regulator of protein synthesis. By blocking mTOR, Rapamycin modulates the mTOR signaling pathway, leading to eIF3θ activation and subsequently influencing translation initiation. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates eIF3θ indirectly by stimulating AMPK, a cellular energy sensor. AMPK activation influences the AMPK/mTOR signaling axis, ultimately leading to eIF3θ activation and impacting translation initiation processes. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Salubrinal activates eIF3θ indirectly by inhibiting ER stress-induced dephosphorylation of eIF2α. By preventing eIF2α dephosphorylation, Salubrinal influences the unfolded protein response (UPR), indirectly activating eIF3θ and regulating translation initiation. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin activates eIF3θ indirectly through AMPK stimulation. By activating AMPK, Metformin modulates the AMPK/mTOR signaling axis, leading to eIF3θ activation and influencing translation initiation processes. | ||||||
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 | 315706-13-9 | sc-202597 | 10 mg | $265.00 | 14 | |
4EGI-1 activates eIF3θ indirectly by disrupting the interaction between eIF4E and 4E-BP1. Through this disruption, 4EGI-1 influences the eIF4E-mediated translation initiation pathway, indirectly activating eIF3θ and impacting overall protein synthesis. | ||||||
ISRIB | 1597403-47-8 | sc-488404 | 10 mg | $300.00 | 1 | |
ISRIB activates eIF3θ indirectly by targeting the integrated stress response (ISR). By inhibiting the ISR, ISRIB modulates the phosphorylation status of eIF2α and indirectly activates eIF3θ, influencing translation initiation processes. | ||||||
Nilotinib | 641571-10-0 | sc-202245 sc-202245A | 10 mg 25 mg | $209.00 $413.00 | 9 | |
Nilotinib activates eIF3θ indirectly by inhibiting c-Abl kinase. Through c-Abl inhibition, Nilotinib influences the c-Abl/mTOR signaling axis, indirectly activating eIF3θ and impacting translation initiation processes. | ||||||
Pimozide | 2062-78-4 | sc-203662 | 100 mg | $104.00 | 3 | |
Pimozide activates eIF3θ indirectly by inhibiting Akt/mTOR signaling. By blocking Akt, Pimozide modulates the Akt/mTOR pathway, leading to eIF3θ activation and subsequently influencing translation initiation. | ||||||
Deferoxamine mesylate | 138-14-7 | sc-203331 sc-203331A sc-203331B sc-203331C sc-203331D | 1 g 5 g 10 g 50 g 100 g | $255.00 $1060.00 $2923.00 $4392.00 $8333.00 | 19 | |
Deferoxamine activates eIF3θ indirectly by stabilizing hypoxia-inducible factor 1-alpha (HIF-1α). Through HIF-1α stabilization, Deferoxamine influences the mTOR/HIF-1α signaling axis, indirectly activating eIF3θ and impacting translation initiation processes. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine activates eIF3θ indirectly by modulating AMPK signaling. Through AMPK activation, Berberine influences the AMPK/mTOR pathway, leading to eIF3θ activation and subsequently impacting translation initiation processes. | ||||||