eIF2C1 Inhibitors
eIF2C1 inhibitors are a class of chemical compounds designed to specifically target and inhibit the function of eIF2C1, also known as Argonaute 1 (AGO1), a crucial component of the RNA-induced silencing complex (RISC). eIF2C1/AGO1 plays a significant role in the regulation of gene expression through the RNA interference (RNAi) pathway. It is involved in the processing and guiding of microRNAs (miRNAs) and small interfering RNAs (siRNAs) to their complementary target mRNA sequences, leading to the repression of gene expression either by promoting mRNA degradation or by inhibiting translation. The precise binding and slicing activities of AGO1 are essential for the effective modulation of gene expression, making it a critical factor in various cellular processes, including development, differentiation, and response to environmental stimuli. Inhibiting eIF2C1 allows researchers to interfere with the RNAi pathway, providing a powerful tool to study the specific contributions of this protein to gene silencing and post-transcriptional regulation.
In research settings, eIF2C1 inhibitors are valuable for dissecting the molecular mechanisms underlying RNAi and the broader implications of RNA-mediated gene regulation. By blocking eIF2C1 activity, scientists can examine how the inhibition affects miRNA and siRNA processing, as well as the downstream effects on gene expression profiles. This inhibition can reveal insights into the role of AGO1 in maintaining cellular homeostasis, regulating developmental processes, and mediating responses to stress. Additionally, eIF2C1 inhibitors allow for the exploration of the interactions between AGO1 and other components of the RNAi machinery, shedding light on the complex networks of protein-protein and protein-RNA interactions that govern gene silencing. Through these studies, the use of eIF2C1 inhibitors enhances our understanding of the critical role of RNA interference in gene regulation, the functional dynamics of Argonaute proteins, and the intricate processes that control post-transcriptional gene expression in various biological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aurintricarboxylic Acid | 4431-00-9 | sc-3525 sc-3525A sc-3525B sc-3525C | 100 mg 1 g 5 g 10 g | $20.00 $31.00 $47.00 $92.00 | 13 | |
This compound inhibits nucleic acid-protein interactions and could prevent AGO1 from binding to miRNAs and siRNAs, thereby inhibiting its role in RNA silencing. | ||||||
Enoxacin | 74011-58-8 | sc-205670 sc-205670A | 500 mg 1 g | $39.00 $48.00 | 2 | |
As a fluoroquinolone antibiotic, it's been shown to enhance RNAi, and by extension, its analogs could be developed to inhibit the biogenesis of miRNAs, potentially reducing AGO1 activity. | ||||||
KU 0063794 | 938440-64-3 | sc-361219 | 10 mg | $209.00 | ||
An inhibitor of mTOR, which regulates cell growth and proliferation; it might indirectly affect AGO1 by altering the cellular environment necessary for RNA silencing. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor could potentially interfere with transcriptional gene silencing (TGS) mediated by AGO1, although its primary known action is activation of genes by demethylation. | ||||||
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $199.00 $599.00 | 24 | |
An inhibitor of neutral sphingomyelinases; although not directly linked to AGO1, it may affect endosomal trafficking, potentially impacting miRNA pathways and AGO1 function. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Similar to 5-azacytidine, this compound is a DNA methyltransferase inhibitor that might affect AGO1-mediated TGS by changing the methylation status of DNA. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
While commonly known as a mitotic inhibitor, Taxol affects numerous cellular processes and might indirectly influence AGO1's role in the cell. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
This antibiotic inhibits RNA synthesis and, although not specific, could reduce AGO1-associated RNA silencing by decreasing RNA availability. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
A flavonoid that has been shown to have various biochemical modulatory effects and could, in theory, affect AGO1 function by modulating signaling pathways involved in RNA silencing. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
An immunosuppressant that inhibits inosine monophosphate dehydrogenase, could theoretically influence AGO1 activity by altering purine synthesis and RNA metabolism. | ||||||