EG625480 Inhibitors
Ssxb14, identified as a member of the SSX family, functions predominantly within the cellular nucleus and is predicted to play a role in gene regulation. This protein is notably implicated in synovial sarcoma, a malignancy characterized by the aberrant growth of soft tissue. Its orthology to human genes such as SSX1, SSX2B, and SSX3 further emphasizes its involvement in complex cellular processes. The nucleus, being a central hub for genetic regulation, signifies Ssxb14's likely role in controlling gene expression. Understanding its function provides a foundation for exploring potential inhibitory mechanisms to regulate its activity. In the context of inhibition, Ssxb14 becomes a target for modulation through intricate pathways. Epigenetic regulation emerges as a key avenue, where inhibitors of histone deacetylases (HDACs) and DNA methyltransferases (DNMTs) can influence the chromatin structure and DNA methylation patterns, respectively. This, in turn, directly impacts Ssxb14 expression by altering the accessibility of the gene's regulatory regions.
Signaling pathways linked to cellular processes also present opportunities for modulation. Inhibitors targeting pathways such as TGF-β, MAPK, PI3K-Akt, mTOR, and NF-κB exert their effects by disrupting downstream signaling cascades associated with cellular proliferation, survival, and stress responses. The indirect impact on Ssxb14 arises from its interconnectedness with these pathways, resulting in altered gene transcription and cellular processes linked to Ssxb14 function. As a target for inhibition, Ssxb14's role in the nucleus, its orthologous relationships, and its implication in a specific type of cancer underscore the complexity of its regulatory networks. Inhibition strategies, spanning epigenetic modulation and disruption of key signaling pathways, provide avenues for future investigations. This nuanced understanding of Ssxb14 and its potential inhibitors contributes to the broader landscape of research exploring the intricacies of gene regulation and its relevance in pathological conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
HDAC inhibitor affecting histone acetylation. Trichostatin A modulates chromatin structure through histone acetylation modifications, influencing gene transcription and cellular processes associated with Ssxb14. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor altering DNA methylation patterns. 5-Azacytidine influences epigenetic regulation, indirectly affecting Ssxb14 expression by modulating chromatin structure and gene transcription. | ||||||
(+)-Nutlin-3 | 675576-97-3 | sc-222085 sc-222085A | 500 µg 1 mg | $92.00 $120.00 | ||
MDM2 inhibitor disrupting MDM2-p53 interaction. Nutlin-3 indirectly influences Ssxb14 by impacting the p53 pathway, altering downstream signaling events associated with gene transcription and cellular processes linked to Ssxb14 function. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
BET bromodomain inhibitor targeting epigenetic readers. JQ1 influences chromatin accessibility, indirectly regulating Ssxb14 expression by altering transcriptional programs and cellular processes associated with Ssxb14 function. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 free base | sc-202651 | 5 mg | $148.00 | 4 | |
G9a histone methyltransferase inhibitor affecting histone methylation patterns. BIX 01294 modulates chromatin structure, indirectly influencing Ssxb14 expression by altering gene transcription and cellular processes associated with Ssxb14 function. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
TGF-β receptor inhibitor disrupting the TGF-β signaling pathway. SB431542 indirectly influences Ssxb14 expression by altering the TGF-β pathway, impacting downstream signaling cascades associated with gene transcription and cellular processes linked to Ssxb14 function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3-kinase inhibitor influencing the PI3K-Akt signaling pathway. LY294002 indirectly regulates Ssxb14 expression by blocking PI3-kinase activity, affecting downstream signaling cascades associated with cellular proliferation, survival, and gene transcription linked to Ssxb14 function. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
NF-κB inhibitor disrupting the NF-κB signaling pathway. BAY 11-7082 indirectly modulates Ssxb14 expression by inhibiting the NF-κB pathway, altering downstream signaling events associated with gene transcription and cellular processes linked to Ssxb14 function. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Histone deacetylase inhibitor affecting histone acetylation. Vorinostat modulates chromatin structure through histone acetylation modifications, influencing gene transcription and cellular processes associated with Ssxb14. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $160.00 $345.00 | 12 | |
mTOR inhibitor targeting the mTOR signaling pathway. AZD8055 indirectly influences Ssxb14 expression by disrupting the mTOR pathway, impacting downstream signaling cascades associated with cellular proliferation, survival, and gene transcription linked to Ssxb14 function. | ||||||