EG624855 Inhibitors
Cks1brt, a retrotransposed duplicate of CDC28 protein kinase 1b, exhibits a predicted multifaceted role in cellular processes, primarily involving its participation in the regulation of the mitotic cell cycle. Its functional repertoire encompasses activities such as cyclin-dependent protein serine/threonine kinase activation, histone binding, and ubiquitin binding, indicating its involvement in key molecular events governing cell division. The orthologous relationship with human CKS1B suggests evolutionary conservation of these functions across species, underscoring the biological significance of Cks1brt. Central to the modulation of Cks1brt is the intricate network of cyclin-dependent kinases (CDKs), vital components orchestrating cell cycle progression. Direct inhibitors targeting CDKs, such as Roscovitine, Purvalanol A, and Dinaciclib, disrupt the normal course of the cell cycle, leading to arrest and subsequent suppression of Cks1brt activity. These inhibitors interfere with the cyclin-dependent protein kinase holoenzyme complex, intricately linked to the regulation of the mitotic cell cycle. Indirect inhibitors, like Cisplatin, exert their influence by inducing DNA damage, activating cell cycle checkpoints, and affecting Cks1brt activity. This underscores the interconnected nature of cell cycle regulation and DNA repair mechanisms, emphasizing the broader implications of Cks1brt in maintaining cellular homeostasis.
In summary, Cks1brt emerges as a pivotal player in the orchestration of mitotic cell cycle dynamics, wielding its influence through multifunctional activities. The general mechanisms of inhibition primarily revolve around the modulation of CDKs, the principal actors in the cell cycle narrative. Direct inhibitors disrupt the finely tuned interplay of CDKs, inducing cell cycle arrest and subsequently affecting Cks1brt function. Indirect inhibitors, through DNA damage induction, further underscore the intricate link between cell cycle regulation and DNA repair processes, implicating Cks1brt in these fundamental cellular activities. The intricate web of molecular interactions involving Cks1brt and its inhibition opens avenues for deeper exploration into the underlying mechanisms governing cell cycle progression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a direct inhibitor of Cks1brt through inhibition of cyclin-dependent kinases (CDKs). By blocking CDKs, it disrupts the cell cycle progression and inhibits the activity of Cks1brt, influencing the regulation of mitotic cell cycle. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
Purvalanol A is a direct inhibitor of Cks1brt by targeting CDKs, leading to cell cycle arrest and inhibiting Cks1brt activity. It influences the regulation of mitotic cell cycle by interfering with key components of the cyclin-dependent protein kinase holoenzyme complex. | ||||||
Dinaciclib | 779353-01-4 | sc-364483 sc-364483A | 5 mg 25 mg | $242.00 $871.00 | 1 | |
Dinaciclib is a direct inhibitor of Cks1brt through potent inhibition of CDKs, causing cell cycle arrest and suppressing Cks1brt activity. It modulates the cyclin-dependent protein kinase holoenzyme complex, impacting the regulation of mitotic cell cycle. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol is a direct inhibitor of Cks1brt through inhibition of CDKs, leading to cell cycle arrest and suppression of Cks1brt activity. It interferes with the cyclin-dependent protein kinase holoenzyme complex, influencing the regulation of mitotic cell cycle. | ||||||
SNS-032 | 345627-80-7 | sc-364621 sc-364621A | 5 mg 10 mg | $169.00 $262.00 | ||
SNS-032 is a direct inhibitor of Cks1brt by targeting CDKs, causing cell cycle arrest and inhibiting Cks1brt activity. It modulates the cyclin-dependent protein kinase holoenzyme complex, influencing the regulation of mitotic cell cycle. | ||||||
AT7519 | 844442-38-2 | sc-364416 sc-364416A sc-364416B sc-364416C | 5 mg 10 mg 100 mg 1 g | $207.00 $246.00 $1025.00 $3065.00 | 1 | |
AT7519 is a direct inhibitor of Cks1brt through inhibition of CDKs, leading to cell cycle arrest and suppression of Cks1brt activity. It interferes with the cyclin-dependent protein kinase holoenzyme complex, influencing the regulation of mitotic cell cycle. | ||||||
R547 | 741713-40-6 | sc-364596 sc-364596A | 2 mg 5 mg | $375.00 $395.00 | ||
R547 is a direct inhibitor of Cks1brt through inhibition of CDKs, causing cell cycle arrest and suppressing Cks1brt activity. It modulates the cyclin-dependent protein kinase holoenzyme complex, impacting the regulation of mitotic cell cycle. | ||||||
NU6027 | 220036-08-8 | sc-215591 | 10 mg | $153.00 | 1 | |
NU6027 is a direct inhibitor of Cks1brt through inhibition of CDKs, leading to cell cycle arrest and suppression of Cks1brt activity. It interferes with the cyclin-dependent protein kinase holoenzyme complex, influencing the regulation of mitotic cell cycle. | ||||||
AZD 5438 | 602306-29-6 | sc-361115 sc-361115A | 10 mg 50 mg | $205.00 $865.00 | ||
AZD5438 is a direct inhibitor of Cks1brt by targeting CDKs, causing cell cycle arrest and inhibiting Cks1brt activity. It modulates the cyclin-dependent protein kinase holoenzyme complex, influencing the regulation of mitotic cell cycle. | ||||||
THZ1 | 1604810-83-4 | sc-507542 | 1 mg | $95.00 | ||
THZ1 is a direct inhibitor of Cks1brt through specific inhibition of CDK7, disrupting the cell cycle and inhibiting Cks1brt activity. It influences the regulation of mitotic cell cycle by targeting key components of the cyclin-dependent protein kinase holoenzyme complex. | ||||||