EG385328 Activators
H2al1n, a member of the H2A histone family, unfolds as a critical player with predicted roles in enabling DNA binding activity and participating in heterochromatin assembly. These functions place H2al1n at the forefront of epigenetic regulation, influencing chromatin structure and organization. The activation of H2al1n involves a sophisticated interplay of chemical modulators that intricately influence its DNA binding activity, ultimately contributing to heterochromatin assembly. The predicted DNA binding activity of H2al1n positions it as a key participant in the dynamic regulation of chromatin architecture. The direct activation by compounds such as trichostatin A, sodium butyrate, and panobinostat, through histone acetylation, highlights the gene's responsiveness to epigenetic modifications. This activation not only supports the immediate enhancement of DNA binding activity but also plays a crucial role in heterochromatin assembly, contributing to the overall chromatin landscape. Indirect activation mechanisms, involving agents like 5-azacytidine, RG108, and betaine, further underscore the intricate relationship between H2al1n and DNA methylation patterns, intricately influencing its DNA binding activity.
In summary, the activation of H2al1n is intricately tied to the modulation of histone acetylation and DNA methylation patterns. This epigenetic regulation directly influences the gene's DNA binding activity, contributing to heterochromatin assembly. The dynamic interplay of chemical modulators showcases the multifaceted nature of H2al1n activation, positioning it as a key player in the intricate machinery orchestrating chromatin dynamics and ultimately influencing cellular processes tied to epigenetic regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, directly activates H2al1n by enhancing histone acetylation, promoting DNA binding activity. This epigenetic modulation triggers heterochromatin assembly processes. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA demethylating agent, indirectly activates H2al1n by influencing DNA methylation patterns, promoting DNA binding activity. This epigenetic modification contributes to heterochromatin assembly. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, a histone deacetylase inhibitor, directly activates H2al1n through enhanced histone acetylation, promoting DNA binding activity. This epigenetic modulation contributes to heterochromatin assembly. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid, a histone deacetylase inhibitor, directly activates H2al1n by promoting histone acetylation, enhancing DNA binding activity. This epigenetic modulation supports heterochromatin assembly. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin activates H2al1n by inhibiting HDAC activity, leading to histone acetylation. This direct activation promotes DNA binding activity and contributes to heterochromatin assembly. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108, a DNA methyltransferase inhibitor, indirectly activates H2al1n by inhibiting DNA methylation, promoting DNA binding activity. This epigenetic modulation supports heterochromatin assembly. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat, a pan-histone deacetylase inhibitor, directly activates H2al1n by enhancing histone acetylation, promoting DNA binding activity. This epigenetic modulation contributes to heterochromatin assembly. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $30.00 $40.00 $55.00 $160.00 $330.00 $580.00 | 2 | |
Betaine indirectly activates H2al1n by influencing DNA methylation patterns, promoting DNA binding activity. This epigenetic modulation supports heterochromatin assembly processes. | ||||||
RGFP966 | 1357389-11-7 | sc-507300 | 5 mg | $115.00 | ||
RGFP966, a specific HDAC3 inhibitor, directly activates H2al1n by enhancing histone acetylation, promoting DNA binding activity. This epigenetic modulation contributes to heterochromatin assembly. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine, a DNA demethylating agent, indirectly activates H2al1n by inhibiting DNA methylation, promoting DNA binding activity. This epigenetic modulation supports heterochromatin assembly. | ||||||