EG229879 Inhibitors
Gm4862, a protein predicted to play a crucial role in various cellular processes, operates at the intersection of multiple signaling pathways, orchestrating cellular proliferation and survival. Its predicted functions encompass intricate interactions within pathways such as PI3K/AKT, MAPK/ERK, PKC/NF-κB, Wnt/GSK-3β/β-catenin, JAK/STAT3, Hedgehog, and others. As a protein associated with cell survival, Gm4862 influences the delicate balance between proliferation and apoptosis.
Inhibition of Gm4862 involves a strategic interference with these intricate signaling cascades. Various inhibitors act on key nodes of these pathways, indirectly influencing Gm4862 expression and function. For instance, PI3K inhibitors disrupt the PI3K/AKT pathway, hindering Gm4862 activation and downstream signaling. MEK inhibitors, targeting the MAPK/ERK pathway, interfere with Gm4862-mediated signaling, arresting cell cycle progression and inducing apoptosis. PKC inhibitors, by suppressing the PKC/NF-κB signaling axis, impact Gm4862 expression, compromising transcriptional activation, and cellular survival. Wnt signaling antagonists modulate the Wnt/GSK-3β/β-catenin pathway, indirectly affecting Gm4862 and suppressing its pro-survival effects. Inhibitors acting on STAT3, Hedgehog, NF-κB, HSP90, and other pathways also contribute to the inhibition of Gm4862. These compounds strategically disrupt the activation and functioning of Gm4862, collectively contributing to a nuanced understanding of the protein's role in cellular homeostasis. Gm4862 inhibition is a multifaceted approach that considers the interconnectedness of signaling pathways, providing a foundation for further investigations into its precise regulatory mechanisms and potential implications in cellular physiology.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Phosphoinositide 3-kinase (PI3K) inhibitor targeting the catalytic subunit. Disrupts the PI3K/AKT pathway, hindering Gm4862 activation and downstream signaling, thus impeding cellular proliferation. | ||||||
Trametinib | 871700-17-3 | sc-364639 sc-364639A sc-364639B | 5 mg 10 mg 1 g | $114.00 $166.00 $947.00 | 19 | |
Mitogen-activated protein kinase kinase (MEK) inhibitor, blocking the MAPK/ERK pathway. Interferes with Gm4862-mediated signaling, arresting cell cycle progression and inducing apoptosis through disruption of vital survival pathways. | ||||||
Enzastaurin | 170364-57-5 | sc-364488 sc-364488A sc-364488B | 10 mg 50 mg 200 mg | $259.00 $612.00 $1721.00 | 3 | |
Protein kinase C (PKC) inhibitor impacting the PKC/NF-κB signaling axis. Suppresses Gm4862 expression by impeding NF-κB translocation to the nucleus, resulting in diminished transcriptional activation and cell survival. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
Wnt signaling antagonist inhibiting β-catenin activity. Modulates the Wnt/GSK-3β/β-catenin pathway, indirectly influencing Gm4862 expression and suppressing its pro-survival effects. | ||||||
Stat3 inhibitor V, stattic | 19983-44-9 | sc-202818 sc-202818A sc-202818B sc-202818C sc-202818D sc-202818E sc-202818F | 25 mg 100 mg 250 mg 500 mg 1 g 2.5 g 5 g | $130.00 $196.00 $274.00 $512.00 $731.00 $1408.00 $2091.00 | 114 | |
STAT3 inhibitor disrupting the JAK/STAT3 pathway. Attenuates Gm4862 activation by inhibiting STAT3 phosphorylation, hindering the transcriptional events necessary for Gm4862-mediated cellular responses. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Hedgehog pathway inhibitor targeting Smoothened (SMO). Alters the Hedgehog signaling cascade, indirectly modulating Gm4862 expression and impeding its role in cell survival and proliferation. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
NF-κB inhibitor preventing nuclear translocation. Disrupts the NF-κB pathway, leading to decreased Gm4862 expression as NF-κB-mediated transcription is inhibited, resulting in compromised cellular survival mechanisms. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
HSP90 inhibitor impacting protein folding and stability. Indirectly influences Gm4862 by destabilizing key signaling proteins, leading to degradation and attenuation of Gm4862-mediated cellular responses. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Proteasome inhibitor targeting chymotrypsin-like activity. Disrupts the ubiquitin-proteasome system, impacting Gm4862 turnover and indirectly modulating its expression, ultimately hindering cellular survival mechanisms. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
GSK-3β inhibitor disrupting the Wnt signaling pathway. Alters Gm4862 expression by preventing GSK-3β-mediated degradation of β-catenin, indirectly influencing its role in cellular proliferation and survival. | ||||||