Date published: 2025-10-11

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EDEM Antibodies

Santa Cruz Biotechnology features a diverse variety of EDEM Antibodies for studying the endoplasmic reticulum-associated degradation (ERAD) pathway. EDEM Antibodies are compatible with multiple research techniques, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). EDEM (ER degradation-enhancing alpha-mannosidase-like protein) plays a crucial role in the quality control of glycoproteins within the endoplasmic reticulum, ensuring that misfolded proteins are efficiently recognized and targeted for degradation. The ERAD pathway is vital for maintaining cellular homeostasis and preventing the accumulation of dysfunctional proteins, which can lead to various diseases. Understanding EDEM function is essential for elucidating the mechanisms of protein folding and degradation in health and disease. Research into EDEM has revealed significant implications for neurodegenerative disorders, cancer, and other pathological conditions. Investigating EDEM's role in protein quality control continues to yield important insights into cellular stress responses and disease mechanisms. EDEM monoclonal antibodies from Santa Cruz Biotechnology enable researchers worldwide to advance scientific understanding of protein quality control mechanisms and their impact on human health.

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EDEM Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

EDEM Antibody (D-1)

sc-377394mouse IgM κ623-651 (h)WB, IP, IF, ELISAm, r, h
5
(5)

EDEM2 Antibody (JD-32)

sc-130460mouse IgG1 κ479-579 (h)IF, IHC(P), ELISAh
1
(1)

EDEM CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

EDEM CRISPR/Cas9 KO Plasmid (h)

sc-401946hGene KnockoutGFP
1
(0)

EDEM HDR Plasmid (h)

sc-401946-HDRhHomology Directed RepairPuromycin
1
(0)

EDEM Double Nickase Plasmid (h)

sc-401946-NIChGene KnockoutPuromycin
1
(0)

EDEM Double Nickase Plasmid (h2)

sc-401946-NIC-2hGene KnockoutPuromycin
1
(0)

EDEM CRISPR/Cas9 KO Plasmid (m)

sc-431403mGene KnockoutGFP0
(0)

EDEM HDR Plasmid (m)

sc-431403-HDRmHomology Directed RepairPuromycin0
(0)

EDEM Double Nickase Plasmid (m)

sc-431403-NICmGene KnockoutPuromycin0
(0)

EDEM Double Nickase Plasmid (m2)

sc-431403-NIC-2mGene KnockoutPuromycin0
(0)

EDEM2 CRISPR/Cas9 KO Plasmid (h)

sc-408453hGene KnockoutGFP0
(0)

EDEM2 HDR Plasmid (h)

sc-408453-HDRhHomology Directed RepairPuromycin0
(0)

EDEM2 Double Nickase Plasmid (h)

sc-408453-NIChGene KnockoutPuromycin0
(0)

EDEM2 Double Nickase Plasmid (h2)

sc-408453-NIC-2hGene KnockoutPuromycin0
(0)

EDEM2 CRISPR/Cas9 KO Plasmid (m)

sc-430847mGene KnockoutGFP0
(0)

EDEM2 HDR Plasmid (m)

sc-430847-HDRmHomology Directed RepairPuromycin0
(0)

EDEM2 Double Nickase Plasmid (m)

sc-430847-NICmGene KnockoutPuromycin0
(0)

EDEM2 Double Nickase Plasmid (m2)

sc-430847-NIC-2mGene KnockoutPuromycin0
(0)

EDEM3 CRISPR/Cas9 KO Plasmid (h)

sc-408476hGene KnockoutGFP
1
(0)

EDEM3 HDR Plasmid (h)

sc-408476-HDRhHomology Directed RepairPuromycin
1
(0)

EDEM3 Double Nickase Plasmid (h)

sc-408476-NIChGene KnockoutPuromycin
1
(0)

EDEM3 Double Nickase Plasmid (h2)

sc-408476-NIC-2hGene KnockoutPuromycin
1
(0)

EDEM3 CRISPR/Cas9 KO Plasmid (m)

sc-426296mGene KnockoutGFP0
(0)

EDEM3 HDR Plasmid (m)

sc-426296-HDRmHomology Directed RepairPuromycin0
(0)

EDEM3 Double Nickase Plasmid (m)

sc-426296-NICmGene KnockoutPuromycin0
(0)

EDEM3 Double Nickase Plasmid (m2)

sc-426296-NIC-2mGene KnockoutPuromycin0
(0)

EDEM CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

EDEM CRISPR Activation Plasmid (h)

sc-401946-ACThGene ActivationPuro, Blast, Hygro
1
(0)

EDEM CRISPR Activation Plasmid (h2)

sc-401946-ACT-2hGene ActivationPuro, Blast, Hygro
1
(0)

EDEM Lentiviral Activation Particles (h)

sc-401946-LAChGene ActivationPuro, Blast, Hygro
1
(0)

EDEM Lentiviral Activation Particles (h2)

sc-401946-LAC-2hGene ActivationPuro, Blast, Hygro
1
(0)

EDEM CRISPR Activation Plasmid (m)

sc-431403-ACTmGene ActivationPuro, Blast, Hygro0
(0)

EDEM CRISPR Activation Plasmid (m2)

sc-431403-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

EDEM Lentiviral Activation Particles (m)

sc-431403-LACmGene ActivationPuro, Blast, Hygro0
(0)

EDEM Lentiviral Activation Particles (m2)

sc-431403-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

EDEM2 CRISPR Activation Plasmid (h)

sc-408453-ACThGene ActivationPuro, Blast, Hygro0
(0)

EDEM2 CRISPR Activation Plasmid (h2)

sc-408453-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

EDEM2 Lentiviral Activation Particles (h)

sc-408453-LAChGene ActivationPuro, Blast, Hygro0
(0)

EDEM2 Lentiviral Activation Particles (h2)

sc-408453-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

EDEM2 CRISPR Activation Plasmid (m)

sc-430847-ACTmGene ActivationPuro, Blast, Hygro0
(0)

EDEM2 CRISPR Activation Plasmid (m2)

sc-430847-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

EDEM2 Lentiviral Activation Particles (m)

sc-430847-LACmGene ActivationPuro, Blast, Hygro0
(0)

EDEM2 Lentiviral Activation Particles (m2)

sc-430847-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

EDEM3 CRISPR Activation Plasmid (h)

sc-408476-ACThGene ActivationPuro, Blast, Hygro
1
(0)

EDEM3 CRISPR Activation Plasmid (h2)

sc-408476-ACT-2hGene ActivationPuro, Blast, Hygro
1
(0)

EDEM3 Lentiviral Activation Particles (h)

sc-408476-LAChGene ActivationPuro, Blast, Hygro
1
(0)

EDEM3 Lentiviral Activation Particles (h2)

sc-408476-LAC-2hGene ActivationPuro, Blast, Hygro
1
(0)

EDEM3 CRISPR Activation Plasmid (m)

sc-426296-ACTmGene ActivationPuro, Blast, Hygro0
(0)

EDEM3 CRISPR Activation Plasmid (m2)

sc-426296-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

EDEM3 Lentiviral Activation Particles (m)

sc-426296-LACmGene ActivationPuro, Blast, Hygro0
(0)

EDEM3 Lentiviral Activation Particles (m2)

sc-426296-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

EDEM siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

EDEM siRNA (h)

sc-43745hGene SilencingN/A
2
(1)

EDEM shRNA Plasmid (h)

sc-43745-SHhGene SilencingPuromycin
2
(1)

EDEM shRNA (h) Lentiviral Particles

sc-43745-VhGene SilencingPuromycin
2
(1)

EDEM siRNA (m)

sc-143293mGene SilencingN/A0
(0)

EDEM shRNA Plasmid (m)

sc-143293-SHmGene SilencingPuromycin0
(0)

EDEM shRNA (m) Lentiviral Particles

sc-143293-VmGene SilencingPuromycin0
(0)

EDEM2 siRNA (h)

sc-77226hGene SilencingN/A
1
(0)

EDEM2 shRNA Plasmid (h)

sc-77226-SHhGene SilencingPuromycin
1
(0)

EDEM2 shRNA (h) Lentiviral Particles

sc-77226-VhGene SilencingPuromycin
1
(0)

EDEM2 siRNA (m)

sc-143294mGene SilencingN/A0
(0)

EDEM2 shRNA Plasmid (m)

sc-143294-SHmGene SilencingPuromycin0
(0)

EDEM2 shRNA (m) Lentiviral Particles

sc-143294-VmGene SilencingPuromycin0
(0)

EDEM3 siRNA (h)

sc-78683hGene SilencingN/A
2
(0)

EDEM3 shRNA Plasmid (h)

sc-78683-SHhGene SilencingPuromycin
2
(0)

EDEM3 shRNA (h) Lentiviral Particles

sc-78683-VhGene SilencingPuromycin
2
(0)

EDEM3 siRNA (m)

sc-143295mGene SilencingN/A0
(0)

EDEM3 shRNA Plasmid (m)

sc-143295-SHmGene SilencingPuromycin0
(0)

EDEM3 shRNA (m) Lentiviral Particles

sc-143295-VmGene SilencingPuromycin0
(0)