Date published: 2025-10-15

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EDD Inhibitors

The EDD protein, also known as E3 ubiquitin-protein ligase UBR5, is a key regulator of cellular processes through its role as an E3 ubiquitin ligase. EDD is involved in ubiquitin-mediated proteolysis, which plays a critical role in maintaining cellular homeostasis by targeting proteins for degradation. As an E3 ligase, EDD facilitates the transfer of ubiquitin molecules onto specific target proteins, marking them for degradation by the proteasome. This process regulates various cellular functions, including protein turnover, signal transduction, DNA repair, and cell cycle progression. Additionally, EDD has been implicated in the regulation of diverse signaling pathways, such as those involved in DNA damage response, transcriptional regulation, and cellular stress responses, highlighting its multifaceted role in cellular physiology. Inhibition of EDD represents a potential strategy to modulate cellular processes regulated by ubiquitin-mediated proteolysis and signaling pathways. Several mechanisms can disrupt EDD function, including interference with its enzymatic activity, substrate recognition, or protein-protein interactions. Small molecules or peptides that specifically target the catalytic site of EDD can inhibit its E3 ligase activity, preventing the ubiquitination of substrate proteins and subsequent proteasomal degradation. Alternatively, compounds that disrupt protein-protein interactions essential for EDD function can interfere with its substrate recognition or subcellular localization, thereby inhibiting its regulatory roles in cellular processes. Furthermore, post-translational modifications or regulatory proteins may modulate EDD activity, offering additional targets for inhibition.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

C646

328968-36-1sc-364452
sc-364452A
10 mg
50 mg
$260.00
$925.00
5
(1)

C646 is a histone acetyltransferase (HAT) inhibitor that specifically targets p300, a HAT involved in EDD regulation. By inhibiting p300, C646 disrupts acetylation events crucial for EDD activation, thereby modulating its function.

SB 202190

152121-30-7sc-202334
sc-202334A
sc-202334B
1 mg
5 mg
25 mg
$30.00
$125.00
$445.00
45
(1)

SB202190 acts as a selective inhibitor of p38 MAPK, a pathway associated with EDD signaling. By blocking p38 MAPK activation, SB202190 indirectly influences EDD, disrupting the downstream events involved in its modulation.

PP 2

172889-27-9sc-202769
sc-202769A
1 mg
5 mg
$92.00
$223.00
30
(1)

PP2 is a potent inhibitor of Src family kinases (SFKs), which play a role in EDD-related pathways. Inhibition of SFKs by PP2 disrupts the signaling cascade leading to EDD modulation, affecting its activation and downstream effects.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Rapamycin inhibits mTOR, a key regulator in cellular pathways linked to EDD. By disrupting mTOR signaling, Rapamycin indirectly modulates EDD, affecting its activation and downstream cellular responses.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002 is a PI3K inhibitor, influencing the PI3K/Akt pathway associated with EDD. Inhibition of PI3K by LY294002 disrupts the signaling cascades regulating EDD, leading to modulation of its activation and cellular effects.

(±)-JQ1

1268524-69-1sc-472932
sc-472932A
5 mg
25 mg
$226.00
$846.00
1
(0)

JQ1 is a bromodomain and extraterminal (BET) protein inhibitor that indirectly modulates EDD. By inhibiting BET proteins, JQ1 affects the transcriptional events linked to EDD, altering its expression and cellular functions.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$63.00
$241.00
136
(2)

U0126 is a MEK1/2 inhibitor targeting the MAPK pathway. By inhibiting MEK1/2, U0126 disrupts the MAPK pathway, influencing EDD indirectly and altering its activation and downstream cellular responses.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

SP600125 is a JNK inhibitor that affects the JNK signaling pathway linked to EDD. Inhibition of JNK by SP600125 modulates EDD indirectly, disrupting the signaling cascades and cellular events involved in its regulation.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Wortmannin is a potent PI3K inhibitor that influences the PI3K/Akt pathway associated with EDD. By inhibiting PI3K, Wortmannin disrupts the signaling cascades regulating EDD, leading to modulation of its activation and effects.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$39.00
$90.00
212
(2)

PD98059 is a selective inhibitor of MEK1, a component of the MAPK pathway. Inhibiting MEK1 with PD98059 disrupts the MAPK pathway, indirectly modulating EDD and altering its activation and downstream cellular responses.